Τίτλος:
Acute effects of smoke exposure on airway and systemic inflammation in forest firefighters
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: The aim of this study was to assess respiratory health and airway and systemic inflammation in professional forest firefighters post firefighting. Methods: A total of 60 firefighters who participated in forest firefighting operations in Greece during 2008 were included in the study. A questionnaire consisting of symptoms and exposure, pulmonary function, atopy, bronchial hyperresponsiveness, and markers of inflammation in induced sputum, serum, and bronchoalveolar lavage (BAL) fluid was assessed. Results: A measurable eosinophilic and neutrophilic inflammation was shown to be induced in the bronchial airways after acute exposure during forest firefighting. This was associated with increased respiratory symptoms from the upper and lower respiratory tract and pulmonary function impairment. Additionally, a measurable systemic inflammatory response was demonstrated. This study showed that acute exposure during forest firefighting significantly augments the intensity of airway and systemic inflammation in relation to the baseline inflammatory background due to chronic exposure. Conclusion: The repeated acute exposures during firefighting augment the burden of chronic airway and systemic inflammation and may eventually lead to allergic sensitization of the airways and increased incidence of rhinitis and asthma after prolonged exposure. © 2018 Gianniou et al.
Συγγραφείς:
Gianniou, N.
Giannakopoulou, C.
Dima, E.
Kardara, M.
Katsaounou, P.
Tsakatikas, A.
Roussos, C.
Koulouris, N.
Rovina, N.
Περιοδικό:
Journal of Asthma and Allergy
Εκδότης:
Dove Medical Press Ltd
Λέξεις-κλειδιά:
biological marker; bronchodilating agent; eosinophil cationic protein; interleukin 13; interleukin 4; interleukin 8; methacholine; salbutamol; tumor necrosis factor; vasculotropin, adult; Article; asthma; atopy; bronchoalveolar lavage fluid; bronchoscopy; cell counting; chest tightness; coughing; disease burden; dyspnea; enzyme linked immunosorbent assay; fire fighter; forced expiratory flow; forced expiratory volume; forced vital capacity; forest fire; functional residual capacity; hemoptysis; human; immune response; incidence; inflammation; inhalation test; leukocyte differential count; Loeffler pneumonia; lung function test; lymphocytic infiltration; macrophage; major clinical study; neutrophil chemotaxis; occupational exposure; prick test; provocation test; questionnaire; residual volume; respiratory function; respiratory tract allergy; respiratory tract inflammation; rhinitis; sensitivity analysis; smoke; smoking; sneezing; spirometry; sputum level; total lung capacity; wheezing
