Τίτλος:
Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
How circulating inflammatory mediators change upon sepsis progression has not been studied. We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. Any increase of endocan was associated with worsening with odds ratio 16.65 (p < 0.0001). This increase was independently associated with progression into acute respiratory distress syndrome (ARDS) as shown after logistic regression analysis (odds ratio 2.91, p: 0.002). Changes of circulating cytokines do not mediate worsening of the critically ill patients. Instead endocan and Ang2 are increased and this may be interpreted as a key-playing role in the pathogenesis of ARDS and septic shock. Any increase of endocan is a surrogate of worsening of the clinical course. © 2017, Springer-Verlag Berlin Heidelberg.
Συγγραφείς:
Ioakeimidou, A.
Pagalou, E.
Kontogiorgi, M.
Antoniadou, E.
Kaziani, K.
Psaroulis, K.
Giamarellos-Bourboulis, E.J.
Prekates, A.
Antonakos, N.
Lassale, P.
Gogos, C.
on behalf of the Hellenic Sepsis Study Group
Περιοδικό:
European Journal of Clinical Microbiology and Infectious Diseases
Λέξεις-κλειδιά:
angiopoietin 2; endocan; gamma interferon; interleukin 10; interleukin 6; interleukin 8; proteoglycan; tumor necrosis factor; unclassified drug; C11orf2 protein, human; cytokine; ESM1 protein, human; proteoglycan; tumor protein; vesicular transport protein, adult respiratory distress syndrome; aged; Article; blood biochemistry; comparative study; controlled study; critically ill patient; cytokine production; disease course; enzyme immunoassay; female; follow up; general condition deterioration; human; major clinical study; male; multiple organ failure; priority journal; prospective study; protein blood level; sepsis; septic shock; Sequential Organ Failure Assessment Score; adult; blood; chemistry; disease exacerbation; enzyme linked immunosorbent assay; longitudinal study; middle aged; organ dysfunction score; pathology; sepsis; serum; very elderly, Adult; Aged; Aged, 80 and over; Cytokines; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Humans; Longitudinal Studies; Male; Middle Aged; Neoplasm Proteins; Organ Dysfunction Scores; Prospective Studies; Proteoglycans; Respiratory Distress Syndrome, Adult; Sepsis; Serum; Vesicular Transport Proteins
DOI:
10.1007/s10096-017-2988-6
