Περίληψη:
Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa. Both diseases are characterized by chronic inflammation, osseous destruction, damage of the supporting soft tissues, similar cellular immune responses and common immunogenetic findings. Although a definite, methodological report associating these diseases is missing from the literature, it is possible that both diseases share a common aetiopathogenic background. This background includes the post-translation modification citrullination, which guides the conversion of the amino acid arginine to citrulline in certain self-proteins, generating neo-epitope structures. This results in reduced self-tolerance, development of autoimmunity and the production of ACPAs. The current hypothesis suggests that certain oral bacteria induce the citrullination of proteins under the action of the enzyme peptidyl arginine deiminase (PAD), which exists in both Porphyromonas gingivalis and inflammatory cells. Antibodies against citrullinated proteins and peptides constitute a common serological finding in both RA and PO. The aim of this review is to map the immunological and serological profiles of PO, and to unveil the parameters that connect PO with the appearance of RA at clinical, prognostic and pathogenetic levels. Until now, there have been no reports sufficiently mapping the immunological profile of PO and defining its aetiopathogenic connection with RA, although a similarity between the immunological profile of PO and RA is highly expected. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Συγγραφείς:
Routsias, J.G.
Goules, J.D.
Goules, A.
Charalampakis, G.
Pikazis, D.
Λέξεις-κλειδιά:
arginine; citrulline; cyclic citrullinated peptide antibody; protein arginine deiminase, autoimmune disease; bone destruction; correlational study; human; immune response; inflammatory cell; nonhuman; periodontitis; Porphyromonas gingivalis; priority journal; prognosis; review; rheumatoid arthritis; serodiagnosis; soft tissue defect, Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Autoimmunity; Chronic Disease; Comorbidity; Disease Progression; Female; Humans; Incidence; Male; Periodontitis; Prognosis; Risk Assessment; Severity of Illness Index
