Τίτλος:
Craniectomy and noggin application in an infant model
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: Noggin is an antagonist of bone morphogenetic proteins
(BMP)-2,-4 and -7. Little data are available regarding its clinical
utility. Two hypotheses were put forward: firstly, that spontaneous
regeneration of calvarial defects with noggin protein would result in
diminished bone volume when compared with calvarial defects not so
treated. Secondly, that centrifugal cranial expansion would remain
undisturbed whether noggin was applied or not. Material and methods: A
unilateral defect of the frontal and parietal bones (2 x 4 cm) was
generated by excising the right coronal suture in 2-month-old minipigs
(n = 10) and in group 1 (n = 5) no further intervention was undertaken.
In the second group (n = 5), a collagen type I tissue fleece and noggin
protein (1.05 mg/ml) were applied. After 4 months the coronal suture
regions of frontal sides were examined in each animal by computed
tomography and non-decalcified histology. Results: Bony gaps of
equivalent size remained in animals of both groups. The differences in
bone volumes of the experimental sides of group I were not statistically
significantly different (p = 0.117) when compared with those of group 2.
A significant difference in the bone volumes of the experimental versus
control (unoperated) sides was found in both group 1 (p = 0.043) and
group 2 (p = 0.043). Internal skull diameters increased by 16.4% in
both groups but the physiological centrifugal cranial expansion remained
undisturbed. Bone densities of the experimental and control sides of
groups I and 2 were not statistically significantly different (both p >
0.05). Conclusions: The first hypothesis was contradicted: the quantity
and quality of spontaneous bone regenerates was not altered by
application of noggin protein. The second hypothesis was confirmed: no
disruption of subsequent cranial development was seen. It may be that a
single application of noggin protein in this study was insufficient.
However, it may well be suggested that the continuous supplementation of
noggin, for example by adenoviral noggin gene transfer may significantly
reduce the quantity of spontaneous bone regeneration in a similar
experiment. (c) 2007 European Association for Cranio-Maxillofacial
Surgery.
Συγγραφείς:
Springer, Ingo N. G.
Warnke, Patrick H.
Terheyden, Hendrik and
Acil, Yahya
Buelhoff, Anne
Kuchenbecker, Solveig
Bolte,
Hendrik
Russo, Paul A. J.
Vairaktaris, Eleftherios G. and
Wiltfang, Joerg
Περιοδικό:
Journal of Cranio-Maxillofacial Surgery
Εκδότης:
Churchill Livingstone
Λέξεις-κλειδιά:
bone-regeneration; noggin; infant; craniectomy
DOI:
10.1016/j.jcms.2007.04.003
