Τίτλος:
Thymic Carcinoma With Multiple Paraneoplastic Disorders: Thymic carcinoma with multiple paraneoplastic disorders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Thymic neoplasms are rare and may run an indolent course. Among them, thymic epithelial carcinoma is exceptional as it may be presented with extensive local invasion and distant metastases. There is a wide spectrum of autoimmune/paraneoplastic syndromes associated with thymic tumors including autoimmune diseases, some of which may precede the diagnosis of thymoma. This article describes a 37-year-old woman with metastatic malignant thymoma and a combination of manifestations from different organs. Vitiligo, Raynaud's phenomenon and anti-centromere antibodies were preceded while eosinophilia, interstitial lung disease, rash, thickening of the skin and asymptomatic cryoglobulinemia were diagnosed concomitantly with the neoplasm. We have reviewed the literature and found only twenty case reports with a cluster of three or more autoimmune/paraneoplastic syndromes in the same patient but none with this unique constellation of disorders. The diversity of thymoma's clinical presentation and laboratory/histological features may cause diagnostic dilemmas and therapeutic challenges. © 2021
Συγγραφείς:
Alexakou, Z.
Liatsos, G.
Vasileiou, N.
Vamvakaris, I.
Mani, I.
Alexopoulou, A.
Περιοδικό:
The American Journal of the Medical Sciences
Λέξεις-κλειδιά:
antineoplastic agent, adult; case report; complication; diagnostic imaging; female; human; paraneoplastic syndrome; thymoma, Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Paraneoplastic Syndromes; Thymoma; Thymus Neoplasms
DOI:
10.1016/j.amjms.2021.04.012
