Τίτλος:
Emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in KPC-2-producing Klebsiella pneumoniae of sequence type 39 during treatment
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Three ceftazidime-avibactam-resistant KPC-2-producing Klebsiella pneumoniae strains of ST39 were isolated in Greece, from rectal swabs of three patients after 10–15 days of treatment. The patients were treated with ceftazidime-avibactam as monotherapy or in combination with colistin. Two of these strains harbored a D179Y or a D179V substitution in the Ω loop of KPC-2, corresponding to KPC-33, or to the novel KPC-57, respectively. The third strain had a 15 amino acid insertion after position 259 in the KPC-2, corresponding to KPC-44. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Galani, I.
Karaiskos, I.
Angelidis, E.
Papoutsaki, V.
Galani, L.
Souli, M.
Antoniadou, A.
Giamarellou, H.
Περιοδικό:
European Journal of Clinical Microbiology and Infectious Diseases
Εκδότης:
Springer Science and Business Media Deutschland GmbH
Λέξεις-κλειδιά:
amikacin; avibactam; avibactam plus ceftazidime; aztreonam; beta lactamase; beta lactamase KPC 2; carbapenem derivative; carbapenemase; cefepime; ceftazidime; ceftriaxone; chloramphenicol; ciprofloxacin; colistin; cotrimoxazole; fosfomycin; gentamicin; imipenem; levofloxacin; meropenem; meropenem plus vaborbactam; piperacillin plus tazobactam; porin; relebactam; sulfonamide; tetracycline; tigecycline; trimethoprim; unclassified drug; antiinfective agent; avibactam, ceftazidime drug combination; azabicyclo derivative; ceftazidime, adaptation; amikacin resistance; amino acid substitution; antibiotic sensitivity; Article; bacterial genome; bacterium culture; bacterium isolation; beta-lactam resistance; carbapenem resistance; chromosome; controlled study; extensive drug resistance; feces culture; gene mutation; genetic variation; Greece; hospitalization; human; intensive care unit; Klebsiella pneumoniae; Klebsiella pneumoniae infection; minimum inhibitory concentration; missense mutation; monotherapy; multidrug resistance; nonhuman; polymerase chain reaction; priority journal; promoter region; rectal swab; replicon; tertiary care center; transposon; whole genome sequencing; case report; drug combination; drug effect; genetics; Klebsiella infection; Klebsiella pneumoniae; microbial sensitivity test; microbiology; multidrug resistance; rectum, Anti-Bacterial Agents; Azabicyclo Compounds; Ceftazidime; Drug Combinations; Drug Resistance, Multiple, Bacterial; Greece; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Rectum
DOI:
10.1007/s10096-020-04000-9
