Τίτλος:
The Use of Norethisterone for the Treatment of Severe Uterine Bleeding in Adolescents: An Audit of Our Experience
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Study Objective: The purpose of this prospective study was to assess the effectiveness of norethisterone (NET) in the management of abnormal uterine bleeding (AUB) in adolescents in a tertiary care center. Design: This was a prospective audit focused on administering high doses of NET in female adolescents with complaints of AUB. Setting: We included female adolescents who presented to our Emergency Gynecological Department or Adolescent Gynecological Outpatient Department from October 2016 to January 2019. Participants: The study included 29 female adolescents aged 11-17 (mean, 13.14) years. Interventions: Patients were administered a daily dose of 10-30 mg, depending on the severity of the condition, bleeding duration, and patient weight. Main Outcome Measures: Cessation of vaginal bleeding. Results: Mean age at menarche of our patient sample was 11.4 years (range, 10.7-14 years). AUB presented at a mean time of 24.6 months after menarche (range, 0-79 months). Blood transfusion was deemed necessary in 9 patients. Bleeding stopped at a mean of 46.1 (range, 8-120) hours after onset of treatment with NET. No serious adverse events were reported with NET administration, with only 3 cases of minor side effects. Conclusion: The use of NET is an effective and reliable treatment option among adolescents for whom control of AUB is desired in the acute setting. © 2019 North American Society for Pediatric and Adolescent Gynecology
Συγγραφείς:
Papapanagiotou, I.K.
Charamanta, M.
Roidi, S.
Al-Achmar, N.S.
Soldatou, A.
Michala, L.
Περιοδικό:
Journal of Pediatric and Adolescent Gynecology
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
hemoglobin; norethisterone; norethisterone; oral contraceptive agent, adolescent; Article; beta thalassemia; blood transfusion; body mass; body weight; child; chronic kidney failure; clinical article; constipation; controlled study; disease duration; disease severity; drowsiness; drug efficacy; drug safety; drug tolerability; dysmenorrhea; female; headache; hematocrit; hemoglobin blood level; human; menarche; menstruation; nausea; non insulin dependent diabetes mellitus; personal experience; priority journal; prospective study; tertiary care center; uterus bicornis; uterus bleeding; vagina bleeding; visual analog scale; clinical audit; treatment outcome; uterus bleeding, Adolescent; Child; Contraceptives, Oral, Hormonal; Female; Humans; Medical Audit; Menarche; Norethindrone; Prospective Studies; Treatment Outcome; Uterine Hemorrhage
DOI:
10.1016/j.jpag.2019.09.002
