Τίτλος:
Correlation of spleen metabolism assessed by 18F-FDG PET with serum interleukin-2 receptor levels and other biomarkers in patients with untreated sarcoidosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background The objective of our study was to assess the possible relationship between splenic F-18-fluorodeoxyglucose (18F-FDG) uptake and other established biochemical markers of sarcoidosis activity. Patients and methods Thirty treatment-naive sarcoidosis patients were prospectively enrolled in this study. They underwent biochemical laboratory tests, including serum interleukin-2 receptor (sIL-2R), serum C-reactive protein, serum angiotensin-I converting enzyme, and 24-h urine calcium levels, and a whole-body combined 18F-FDG PET/computed tomography (PET/CT) scan as a part of an ongoing study at our institute. These biomarkers were statistically compared in these patients. Results A statistically significant linear dependence was detected between sIL-2R and log-transformed spleen-average standard uptake value (SUV avg) (R 2 =0.488, P<0.0001) and log-transformed spleen-maximum standard uptake value (SUV max) (R 2 =0.490, P<0.0001). sIL-2R levels and splenic size correlated linearly (Pearson's r=0.373, P=0.042). Multivariate linear regression analysis revealed that this correlation remained significant after age and sex adjustment (β=0.001, SE=0.001, P=0.024). No statistically significant associations were detected between (a) any two serum biomarkers or (b) between spleen-SUV measurements and any serum biomarker other than sIL-2R. Conclusion Our analysis revealed an association between sIL-2R levels and spleen 18F-FDG uptake and size, whereas all other serum biomarkers were not significantly associated with each other or with PET 18F-FDG uptake. Our results suggest that splenic inflammation may be related to the systemic inflammatory response in sarcoidosis that may be associated with elevated sIL-2R levels. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Kalkanis, A.
Kalkanis, D.
Drougas, D.
Vavougios, G.D.
Datseris, I.
Judson, M.A.
Georgiou, E.
Περιοδικό:
Nuclear Medicine Communications
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
biological marker; C reactive protein; calcium; dipeptidyl carboxypeptidase; fluorodeoxyglucose f 18; interleukin 2 receptor; biological marker; fluorodeoxyglucose f 18; interleukin 2 receptor, adult; Article; calcium urine level; chemical parameters; clinical article; computer assisted emission tomography; controlled study; drug uptake; female; human; male; PET-CT scanner; prospective study; protein blood level; sarcoidosis; spleen; spleen function; spleen metabolism; splenomegaly; standard uptake value; tissue metabolism; whole body scintiscanning; blood; diagnostic imaging; metabolism; positron emission tomography; sarcoidosis; spleen; transport at the cellular level, Adult; Biological Transport; Biomarkers; Female; Fluorodeoxyglucose F18; Humans; Male; Positron-Emission Tomography; Receptors, Interleukin-2; Sarcoidosis; Spleen
DOI:
10.1097/MNM.0000000000000431
