Περίληψη:
Diabetes complications increase with disease duration. No study was performed on the relationship between aortic stiffness and diabetes duration, taking into account the respective influence of such factors on macro- and microcirculation. In total, 618 subjects with type 2 diabetes (259 men) attending the Department of Internal Medicine of Tizi Ouzou Hospital (Algeria) were studied in collaboration with Hotel-Dieu Hospital (Paris, France). Brachial blood pressure (BP), anthropometric, clinical and biological data were evaluated. Aortic stiffness was estimated by carotid-femoral pulse wave velocity (PWV). From lower to higher tertile of diabetes duration, age, BP and PWV (10.1±2.7 to 12.3±2.8 m s-1) increased, while diabetes control and renal function worsened (all P<0.01). Diabetes duration was independently associated with PWV (R2 =0.035, P<0.0001), even after adjustment for age, BP, heart rate, cardiovascular events and metabolic syndrome. Diabetes duration was significantly correlated to the prevalence of microalbuminuria (OR (95% CL) 1.3 (1.06-1.63), P=0.01), independently of age, sex, BP and renal function. Increased aortic stiffness was independently associated with the prevalence of cardiovascular events (P<0.001), reaching its maximal value above the first 2 years of diabetes duration. In conclusion, diabetes duration is an independent determinant of aortic stiffness in subjects with type 2 diabetes, representing about 4% of PWV variability. Diabetes duration is associated with microvascular complications independently of renal function, and with macrovascular complications through the presence of increased aortic stiffness. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Συγγραφείς:
Agnoletti, D.
Mansour, A.S.
Zhang, Y.
Protogerou, A.D.
Ouerdane, S.
Blacher, J.
Safar, M.E.
Λέξεις-κλειδιά:
adult; age; Algeria; anthropometry; arterial stiffness; Article; blood pressure; cardiovascular disease; carotid artery pulse; circulation; clinical study; controlled study; correlational study; diabetes control; disease association; disease control; disease duration; female; femoral artery; France; heart rate; human; insulin treatment; intersectoral collaboration; kidney dysfunction; kidney function; macrocirculation; major clinical study; male; metabolic syndrome X; microalbuminuria; microcirculation; middle aged; non insulin dependent diabetes mellitus; prevalence; pulse wave; sex difference; aged; albuminuria; cardiovascular disease; complication; cross-sectional study; microcirculation; non insulin dependent diabetes mellitus; pathophysiology, Adult; Aged; Albuminuria; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Microcirculation; Middle Aged; Pulse Wave Analysis; Vascular Stiffness
