Τίτλος:
Prevalence of Symptomatic Intracranial Atherosclerosis in Caucasians: A Prospective, Multicenter, Transcranial Doppler Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
BACKGROUND: There are limited data available regarding symptomatic intracranial atherosclerosis (SIA) prevalence in Caucasians. We sought to investigate SIA prevalence among Caucasian patients hospitalized with acute cerebral ischemia (ACI) in a prospective, multicenter Transcranial Doppler sonography (TCD) study. METHODS: Consecutive patients with ACI were prospectively evaluated with TCD over a 24-month-period. The previously validated criteria of SONIA trial were used for detection of >50% intracranial stenosis with TCD. Brain angiography was performed to confirm the diagnosis in cases with abnormal TCD findings. SIA was diagnosed when there was evidence of a cerebral infarction in the territory of the stenotic artery (identified by TCD and confirmed by Magnetic resonance angiography [MRA]/Computed tomography angiography [CTA]). RESULTS: A total of 467 consecutive patients with ACI (60.4% men, mean age 58 ± 14 years) were evaluated. SIA was documented in 43 patients (9.2%; 95%CI: 6.9%-12.2%). The most common SIA location was M1MCA (34.9%) followed by TICA (18.8%). Diabetes mellitus (OR: 4.25, 95%CI: 2.18-8.26; P < .001) and hypertension (OR: 2.41, 95%CI: 1.02-5.67; P = .045) were independently associated with SIA on multivariate models adjusting for potential confounders. CONCLUSIONS: SIA was identified in almost 10% of patients admitted with symptoms of ACI. These preliminary findings support further collaborative initiatives among stroke physicians to increase the yield of SIA detection in Caucasian patients with ACI. © 2012 by the American Society of Neuroimaging.
Συγγραφείς:
Tsivgoulis, G.
Vadikolias, K.
Heliopoulos, I.
Katsibari, C.
Voumvourakis, K.
Tsakaldimi, S.
Boutati, E.
Vasdekis, S.N.
Athanasiadis, D.
Al-Attas, O.S.
Charalampidis, P.
Stamboulis, E.
Piperidou, C.
Περιοδικό:
Journal of Neuroimaging
Λέξεις-κλειδιά:
adult; article; brain angiography; brain atherosclerosis; brain infarction; brain ischemia; Caucasian; computed tomographic angiography; coronary artery disease; diabetes mellitus; female; heart atrium fibrillation; human; hypercholesterolemia; hypertension; magnetic resonance angiography; major clinical study; male; middle aged; multicenter study; prevalence; transcranial doppler; transient ischemic attack; brain atherosclerosis; brain ischemia; clinical trial; comorbidity; Doppler echography; echography; epidemiology; ethnology; prospective study; reproducibility; risk factor; sensitivity and specificity; statistics and numerical data; symptom assessment, Brain Ischemia; Causality; Comorbidity; European Continental Ancestry Group; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Prevalence; Prospective Studies; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Symptom Assessment; Ultrasonography, Doppler, Transcranial
DOI:
10.1111/j.1552-6569.2012.00707.x
