Τίτλος:
New-onset diabetes and cardiovascular events in essential hypertensives: A 6-year follow-up study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Controversy still exists regarding the impact of new-onset diabetes (NOD) on CV outcomes among patients with hypertension. Our aim was to determine the incidence of NOD in essential hypertensives and to evaluate its association with major cardiovascular (CV) events. Methods: We followed-up for a mean period of 6 years 1572 essential hypertensives (mean age 54.3 years, 696 males) for the incidence of NOD, as well as of fatal and non-fatal coronary artery disease and stroke. Based on the development of NOD, the cohort was divided into patients with pre-existing diabetes (10%), patients with NOD (10%) and those who remained free from diabetes. Results: During the follow-up period, new or recurrent cases of coronary artery disease and stroke events occurred at a rate of 5.6% (n = 88) and 4.65% (n = 73). The independent predictors for NOD were age (OR = 1.026, p = 0.041), waist circumference (OR = 1.044, p < 0.001), family history of diabetes (OR = 2.173, p = 0.003) and systolic BP at follow-up (OR 1.022, p = 0.044). The presence of NOD was independently associated with greater incidence of stroke (HR 2.404, p = 0.046), along with age (HR 1.078, p < 0.001), duration of hypertension (HR 1.039, p = 0.017) and office systolic blood pressure at follow-up (HR 1.022, p = 0.026), whereas development of NOD had no relationship with the incidence of coronary artery disease. Conclusions: Our findings indicate the high incidence of NOD and its close association with stroke in essential hypertension. Poorer control of hypertension appears to be a common denominator of both NOD and stroke in this setting. © 2010 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Tsiachris, D.
Tsioufis, C.
Thomopoulos, C.
Syrseloudis, D.
Antonakis, V.
Lioni, L.
Kallikazaros, I.
Makris, T.
Papademetriou, V.
Stefanadis, C.I.
Περιοδικό:
International Journal of Cardiology
Λέξεις-κλειδιά:
adult; age; article; cardiovascular disease; cardiovascular risk; clinical evaluation; cohort analysis; controlled study; coronary artery disease; diabetes mellitus; disease association; disease course; disease duration; disease severity; essential hypertension; family history; female; follow up; human; incidence; independent variable; major clinical study; male; new onset diabetes mellitus; predictor variable; priority journal; recurrent disease; stroke; systolic blood pressure; waist circumference, Age of Onset; Cardiovascular Diseases; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Predictive Value of Tests; Risk Factors
DOI:
10.1016/j.ijcard.2010.08.041
