Τίτλος:
Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Coxsackievirus and adenovirus receptor (CAR) expression on tumor cells is associated with sensitivity to adenoviral infection, being considered as a surrogate marker for monitoring and/or predicting adenovirus-mediated gene therapy. The aim of this study was to evaluate the clinical significance of CAR expression in human benign and malignant thyroid lesions. CAR protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 107 patients with benign and malignant lesions and was statistically analyzed in relation to histopathologic type; tumor size; lymph node metastasis; capsular, lymphatic and vessel invasion; as well as follicular cells' proliferative capacity. CAR immunoreactivity was characterized as negative/weak in 53 (49.53%), moderate in 31 (28.97%) and strong in 23 (21.50%) of 107 thyroid cases. CAR immunoreactivity was significantly increased in malignant compared with that in benign thyroid lesions (p = 0.00002). Both malignant and benign thyroid lesions with enhanced follicular cells' proliferative capacity showed significantly increased CAR immunoreactivity (p = 0.00027). In malignant thyroid lesions, enhanced CAR immunoreactivity was significantly associated with larger tumor size (p = 0.0067). The current data revealed that CAR immunoreactivity could be considered of diagnostic utility in thyroid neoplasia. Further research effort is warranted to delineate whether CAR could be considered clinically important for both diagnosis and future (gene) therapeutic applications in thyroid neoplasia. © 2010 APMIS.
Συγγραφείς:
Giaginis, C.
Zarros, A.
Alexandrou, P.
Klijanienko, J.
Delladetsima, I.
Theocharis, S.
Περιοδικό:
APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica
Λέξεις-κλειδιά:
coxsackie virus and adenovirus receptor, adult; anaplastic carcinoma; article; benign tumor; cancer invasion; cancer size; cell proliferation; controlled study; distant metastasis; female; Hashimoto disease; human; human tissue; lymph node metastasis; lymph vessel; major clinical study; male; priority journal; protein expression; thyroid carcinoma; thyroid follicle cell; thyroid follicular carcinoma; thyroid hyperplasia; thyroid medullary carcinoma; thyroid nodule; thyroid papillary carcinoma, Adult; Aged; Female; Humans; Immunohistochemistry; Male; Middle Aged; Receptors, Virus; Thyroid Neoplasms
DOI:
10.1111/j.1600-0463.2009.02582.x
