Τίτλος:
The effect of sexual hormone abnormalities on proximal femur bone mineral density in hemodialysis patients and the possible role of RANKL
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Sexual hormone concentrations are commonly affected in chronic renal failure. The contribution of sex steroids to bone turnover regulation implies that sex steroid's dysfunction may be implicated in the emergence of renal osteodystrophy. This study was conducted to evaluate sex steroids and gonadotrophins in hemodialysis (HD) patients and to investigate their role in bone homeostasis in concert with other hormones and cytokines. Bone mineral density (BMD) at the proximal femur and intact parathyroid hormone (iPTH), osteoprotegerin, soluble receptor activator of NF-κB ligand (sRANKL), prolactin, total testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in serum samples in 42 patients, 21 men and 21 women, on maintenance HD therapy. Possible associations between clinical characteristics, biochemical parameters, and BMD values were investigated. In male HD patients, the testosterone concentration declined significantly with aging, whereas the estradiol level increased with longer duration of HD. Concurrently, testosterone correlated negatively with sRANKL concentrations (r = -0.520, p = 0.016). Luteinizing hormone levels in male patients demonstrated statistically significant negative correlations with BMD values of the proximal femur. In the entire cohort of patients, FSH and LH were negatively associated with absolute values of proximal femur BMD. Gonadotrophin and sexual hormone concentrations in HD patients are associated with bone mineral status and consequently their derangements appear to contribute to the development of bone composition abnormalities in different types of renal osteodystrophy. Furthermore, testosterone's association with sRANKL levels in male HD patients suggests that RANKL may mediate the effect of testosterone on bone metabolism in these patients. Journal compilation © 2008 International Society for Hemodialysis.
Συγγραφείς:
Doumouchtsis, K.K.
Kostakis, A.I.
Doumouchtsis, S.K.
Grapsa, E.I.
Passalidou, I.A.
Tziamalis, M.P.
Poulakou, M.V.
Vlachos, I.S.
Perrea, D.N.
Περιοδικό:
Hemodialysis International
Λέξεις-κλειδιά:
cytokine; estradiol; follitropin; gonadotropin; luteinizing hormone; osteoclast differentiation factor; osteoprotegerin; parathyroid hormone; prolactin; sex hormone; testosterone; estradiol; follitropin; gonadotropin derivative; immunoglobulin enhancer binding protein; luteinizing hormone; osteoprotegerin; parathyroid hormone; prolactin; testosterone, adult; aged; aging; article; bone density; bone malformation; bone metabolism; clinical article; cohort analysis; controlled study; correlation analysis; disease association; endocrine disease; female; femur; hemodialysis; homeostasis; hormone blood level; human; male; protein analysis; protein blood level; protein function; renal osteodystrophy; statistical significance; treatment duration; bone density; chronic kidney failure; estradiol blood level; follitropin blood level; hemodialysis patient; hormone deficiency; hormone determination; luteinizing hormone blood level; maintenance therapy; parathyroid hormone blood level; pathophysiology; prolactin blood level; protein protein interaction; renal osteodystrophy; testosterone blood level, Adult; Aged; Aged, 80 and over; Bone Density; Female; Femur; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Humans; Kidney Failure, Chronic; Luteinizing Hormone; Male; Middle Aged; RANK Ligand; Reference Values; Renal Dialysis; Testosterone
DOI:
10.1111/j.1542-4758.2008.00249.x
