Τίτλος:
South-to-North gradient in lipid peroxidation in men with stable
coronary artery disease in Europe
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims A South-to-North gradient across Europe exists for the incidence of
coronary artery disease (CAD) rates. Low-density lipoprotein (LDL)
oxidation is a hallmark of atherosclerosis and CAD development. The aim
of our study was to determine whether differences exist in the degree of
LDL oxidation in stable CAD patients from different regions of Europe.
Methods and results A cross-sectional multicentre study included 790
stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six
European countries in three regions by latitude: Northern (Finland and
Sweden), Central (Germany), and Southern (Greece, Spain, and Italy).
Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and
lipid profile were significantly associated with oxLDL. The Italian
participants had the highest oxLDL levels. A sensitivity analysis showed
the models yielded higher adjusted oxLDL values in Northern (63.8 U/L)
than in Central (57.6 U/L) and Southern populations (56.5 U/L), P <
0.001, after excluding Italian subjects. The probability of Southern
Europe scoring the lowest oxLDL levels was > 71% in all fitted models.
Conclusion Our findings suggest a gradient in LDL oxidation from
Southern to Northern Europe that consistently holds for all levels of
LDL, except for Italy; this country displays the highest levels in
Europe, for unknown reasons.
Συγγραφείς:
Grau, Maria
Guxens, Monica
Subirana, Isaac
Fito, Montserrat
and Covas, Maria-Isabel
Jacquemin, Benedicte
Sunyer, Jordi and
Lanki, Timo
Picciotto, Sally
Bellander, Tom
Katsouyanni,
Klea
Schneider, Alexandra
Peters, Annette
Marrugat, Jaume
and AIRGENE Study Grp
Περιοδικό:
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
atherosclerosis; lipid peroxidation; oxidative stress; epidemiology;
coronary artery disease
DOI:
10.1093/eurheartj/ehm446
