Τίτλος:
Polymorphisms of genes coding for ghrelin and its receptor in relation
to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast
cancer risk: a case-control study nested within the European Prospective
Investigation into Cancer and Nutrition (EPIC)
Περίληψη:
Ghrelin, an endogenous ligand for the growth hormone secretagogue
receptor, has two major functions: the stimulation of the growth hormone
production and the stimulation of food intake. Accumulating evidence
also suggests a role of ghrelin in cancer development. We conducted a
case-control study on 1359 breast cancer cases and 2389 matched
controls, nested within the European Prospective Investigation into
Cancer and Nutrition, to examine the association of common genetic
variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR)
with anthropometric measures, circulating insulin growth factor I
(IGF-I) and insulin-like growth factor-binding protein 3 and breast
cancer risk. Pair-wise tagging was used to select the 15 polymorphisms
that represent the majority of common genetic variants across the GHRL
and GHSR genes. A significant increase in breast cancer risk was
observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2;
95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide
polymorphism rs375577 was associated with a 5% increase in IGF-I levels
(P = 0.01). A number of GHRL and GHSR polymorphisms were associated with
body mass index (BMI) and height (P between < 0.01 and 0.04). The
false-positive report probability (FPRP) approach suggests that these
results are noteworthy (FPRP < 0.20). The results presented here add to
a growing body of evidence that GHRL variations are associated with BMI.
Furthermore, we have observed evidence for association of GHRL
polymorphisms with circulating IGF-I levels and with breast cancer risk.
These associations, however, might also be due to chance findings and
further large studies are needed to confirm our results.
Συγγραφείς:
Dossus, Laure
Mckay, James D.
Canzian, Federico
Wilkening,
Stefan
Rinaldi, Sabina
Biessy, Carine
Olsen, Anja and
Tjonneland, Anne
Jakobsen, Marianne U.
Overvad, Kim and
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine and
Fournier, Agnes
Linseisen, Jakob
Lukanova, Annekatrin and
Boeing, Heiner
Fisher, Eva
Trichopoulou, Antonia
Georgila,
Christina
Trichopoulos, Dimitrios
Palli, Domenico
Krogh,
Vittorio
Tumino, Rosario
Vineis, Paolo
Quiros, Jose Ramon
and Sala, Nuria
Martinez-Garcia, Carmen
Dorronsoro, Miren and
Chirlaque, Maria-Dolores
Barricarte, Aurelio
van Duijnhoven,
Franzel J. B.
Bueno-de-Mesquita, H. B.
van Gils, Carla H. and
Peeters, Petra H. M.
Hallmans, Goran
Lenner, Per
Bingham,
Sheila
Khaw, Kay Tee
Key, Tim J.
Travis, Ruth C. and
Ferrari, Pietro
Jenab, Mazda
Riboli, Elio
Kaaks, Rudolf
