Τίτλος:
Implications for a role of interleukin-23 in the pathogenesis of chronic
gastritis and of peptic ulcer disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study aimed to investigate the role of gastric mucosa for
the secretion of interleukin (IL)-23 in chronic gastritis. One hundred
and one patients were enrolled; 47 with duodenal ulcer, 33 with gastric
ulcer and 31 with chronic gastritis. Biopsies were incubated in the
absence/presence of endotoxins. Supernatants were collected and IL-23
and IL-1 beta were measured by enzyme-linked immunosorbent assay.
Scoring of gastritis was performed according to the updated Sydney
score. Patients with duodenal and gastric ulcer and those with chronic
gastritis had similar scores of gastritis. IL-23 was higher in
supernatants of tissue samples of Helicobacter pylori-positive than of
H. pylori-negative patients. No differences were recorded in
concentrations of IL-23 and IL-1 beta between patients with duodenal
ulcer, gastric ulcer and chronic gastritis. Positive correlations were
found between IL-23 of patients with both duodenal and gastric ulcer and
chronic gastritis and the degree of infiltration of neutrophils and
monocytes. Similar correlations were observed between IL-23 and IL-1
beta. IL-23 secreted by the gastric mucosa could be implicated in the
pathogenesis of chronic gastritis. IL-23 was released in the presence of
H. pylori from the inflamed gastric mucosa and followed the kinetics of
IL-1 beta.
Συγγραφείς:
Koussoulas, V.
Vassiliou, S.
Giamarellos-Bourboulis, E. J. and
Tassias, G.
Kotsaki, A.
Barbatzas, C.
Tzivras, M.
Περιοδικό:
Clinical and Experimental Immunology
Λέξεις-κλειδιά:
chronic gastritis; gastric mucosa; IL-23; proinflammatory cytokines
DOI:
10.1111/j.1365-2249.2008.03859.x
