Τίτλος:
Anthropometric Measures, Physical Activity, and Risk of Glioma and
Meningioma in a Large Prospective Cohort Study
Περίληψη:
Body fatness has been associated with increased risk of a number of
hormone-dependent cancers. Recent studies suggest that body mass index
(BMI) may be related to meningiomas, which are more common in women than
men, and for which estrogens are believed to play a role. Using data
from a large European propective cohort, 203 incident cases of
meningioma and 340 cases of glioma were included in the analysis for
measures of body fat, height, and physical activity among 380,775
participants. All analyses were conducted using Cox proportional hazards
model and controlling for age, sex, country, and education. A 71%
increase in risk of meningioma was observed among men and women in the
top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73,
P-trend = 0.01). A positive association was also observed for BMI and
meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with
a BMI of 20-24.9, P-trend = 0.05). An association with height and
meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10
cm increase). In contrast, no associations were observed for height and
different measures of body fat and risk of glioma. Physical activity was
not related to either type of brain tumors. Results from this study
support an increase in risk of meningioma with higher body fatness among
both men and women. No association was observed between anthropometric
measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011
AACR.
Συγγραφείς:
Michaud, Dominique S.
Bove, Gerald
Gallo, Valentina and
Schlehofer, Brigitte
Tjonneland, Anne
Olsen, Anja
Overvad,
Kim
Dahm, Christina C.
Teucher, Brigit
Boeing, Heiner and
Steffen, Annika
Trichopoulou, Antonia
Bamia, Christina and
Kyrozis, Andreas
Sacerdote, Carlotta
Agnoli, Claudia
Palli,
Domenico
Tumino, Rosario
Mattiello, Amalia and
Bueno-de-Mesquita, H. Bas
Peeters, Petra H. M.
May, Anne M. and
Barricarte, Aurelio
Chirlaque, Maria-Dolores
Dorronsoro, Miren
and Jose Sanchez, Maria
Rodriguez, Laudina
Duell, Eric J. and
Hallmans, Goran
Melin, Beatrice S.
Manjer, Jonas
Borgquist,
Signe
Khaw, Kay-Tee
Wareham, Nick
Allen, Naomi E. and
Travis, Ruth C.
Romieu, Isabelle
Vineis, Paolo
Riboli, Elio
