Τίτλος:
Associations between BODE Index and Systemic Inflammatory Biomarkers in
COPD
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: COPD is a multicomponent disease and systemic inflammation
represents one of the possible mechanisms responsible for its systemic
manifestations, including skeletal muscle weakness and cachexia.
Fat-free mass index (FFMI) that reflects the skeletal muscle mass, has
been shown to be associated with both dyspnoea and exercise capacity. We
hypothesized that the multidimensional BODE index, that reflects the
multicomponent nature of COPD, might be related to biomarkers of
systemic inflammation. We further evaluated associations between FFMI
and systemic inflammation. Methods: BODE index and FFMI were calculated
in 222 stable COPD patients and 132 smokers or ex-smokers with normal
lung function. Systemic inflammation was evaluated with the measurement
of leptin, adiponectin, CRP, IL-6, and TNF-alpha in serum samples of
COPD patients. Results: In patients with COPD, both BODE index and FFMI
presented significant positive and negative associations respectively
with leptin levels (R-2 0.61 and 0.65, respectively), whereas FFMI
presented an additional negative association with the levels of
TNF-alpha (R-2 0.38). No significant associations were observed in
smokers or ex-smokers with normal lung function. Conclusions: Both BODE
index and FFMI, are related to the circulating levels of leptin in
patients with COPD, suggesting a possible role for leptin in the
systemic component of COPD. The additional association of FFMI with
TNF-alpha may further support a role of systemic inflammation in muscle
wasting in COPD.
Συγγραφείς:
Gaki, Eleni
Kontogianni, Konstantina
Papaioannou, Andriana I.
and Bakakos, Petros
Gourgoulianis, Konstantinos I.
Kostikas,
Konstantinos
Alchanatis, Manos
Papiris, Spyridon
Loukides,
Stelios
Περιοδικό:
COPD: Journal of Chronic Obstructive Pulmonary Disease
Εκδότης:
Taylor and Francis Inc.
Λέξεις-κλειδιά:
COPD; Cytokines; CRP; Adipose tissue; Nutrition; FFMI
DOI:
10.3109/15412555.2011.619599
