Περίληψη:
Evidence on the association between dietary flavonoids and lignans and
breast cancer (BC) risk is inconclusive, with the possible exception of
isoflavones in Asian countries. Therefore, we investigated prospectively
dietary total and subclasses of flavonoid and lignan intake and BC risk
according to menopause and hormonal receptor status in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The
study included 334,850 women, mostly aged between 35 and 70 years from
ten European countries. At baseline, country-specific validated dietary
questionnaires were used. A flavonoid and lignan food composition
database was developed from the US Department of Agriculture, the
Phenol-Explorer and the UK Food Standards Agency databases. Cox
regression models were used to analyse the association between dietary
flavonoid/lignan intake and the risk of developing BC. During an average
11.5-year follow-up, 11,576 incident BC cases were identified. No
association was observed between the intake of total flavonoids
[hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 %
confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones
(HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans
(HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC
risk. The stratification of the results by menopausal status at
recruitment or the differentiation of BC cases according to oestrogen
and progesterone receptors did not affect the results. This study shows
no associations between flavonoid and lignan intake and BC risk, overall
or after taking into account menopausal status and BC hormone receptors.
Συγγραφείς:
Zamora-Ros, Raul
Ferrari, Pietro
Gonzalez, Carlos A. and
Tjonneland, Anne
Olsen, Anja
Bredsdorff, Lea
Overvad, Kim
and Touillaud, Marina
Perquier, Florence
Fagherazzi, Guy and
Lukanova, Annekatrin
Tikk, Kaja
Aleksandrova, Krasimira and
Boeing, Heiner
Trichopoulou, Antonia
Trichopoulos, Dimitrios and
Dilis, Vardis
Masala, Giovanna
Sieri, Sabina
Mattiello,
Amalia
Tumino, Rosario
Ricceri, Fulvio
Bueno-de-Mesquita, H.
Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Skeie, Guri
and Engeset, Dagrun
Menendez, Virginia
Travier, Noemie and
Molina-Montes, Esther
Amiano, Pilar
Chirlaque, Maria-Dolores and
Barricarte, Aurelio
Wallstrom, Peter
Sonestedt, Emily
Sund,
Malin
Landberg, Rikard
Khaw, Kay-Thee
Wareham, Nicholas J.
and Travis, Ruth C.
Scalbert, Augustin
Ward, Heather A. and
Riboli, Elio
Romieu, Isabelle
