Περίληψη:
Epidemiological data regarding tea and coffee consumption and risk of
esophageal cancer (EC) is still inconclusive. We examined the
association of tea and coffee consumption with EC risk among 442,143 men
and women without cancer at baseline from 9 countries of the European
Prospective Investigation into Cancer and Nutrition. Tea and coffee
intakes were recorded using country-specific validated dietary
questionnaires. Cox regression models were used to analyze the
relationships between tea and coffee intake and EC risk. During a mean
follow-up of 11.1 years, 339 participants developed EC, of which 142
were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous
cell carcinoma (ESCC). In the multivariable models, no significant
associations between tea (mostly black tea), and coffee intake and risk
of EC, EAC and ESCC were observed. In stratified analyses, among men
coffee consumption was inversely related to ESCC (HR for comparison of
extreme tertiles 0.42, 95% CI 0.20-0.88; p-trend = 0.022), but not
among women. In current smokers, a significant and inverse association
was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93;
p-trend = 0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73;
p-trend = 0.011). However, no statistically significant findings were
observed using the continuous variable (per 100 mL/d). These data did
not show a significant association between tea and coffee consumption
and EC, EAC and ESCC, although a decreased risk of ESCC among men and
current smokers is suggested, but need to be confirmed in further
prospective studies including more cases.
Συγγραφείς:
Zamora-Ros, Raul
Lujan-Barroso, Leila
Bueno-de-Mesquita, H.
B(as)
Dik, Vincent K.
Boeing, Heiner
Steffen, Annika and
Tjonneland, Anne
Olsen, Anja
Bech, Bodil Hammer
Overvad, Kim
and Boutron-Ruault, Marie-Christine
Racine, Antoine
Fagherazzi,
Guy
Kuhn, Tilman
Katzke, Verena
Trichopoulou, Antonia and
Lagiou, Pagona
Trichopoulos, Dimitrios
Tumino, Rosario and
Panico, Salvatore
Vineis, Paolo
Grioni, Sara
Palli, Domenico
and Weiderpass, Elisabete
Skeie, Guri
Maria Huerta, Jose and
Sanchez, Maria-Jose
Argueelles, Marcial
Amiano, Pilar and
Ardanaz, Eva
Nilsson, Lena
Wallner, Bengt
Lindkvist, Bjorn
and Wallstrom, Peter
Peeters, Petra H. M.
Key, Timothy J. and
Khaw, Kay-Thee
Wareham, Nicholas J.
Freisling, Heinz and
Stepien, Magdalena
Ferrari, Pietro
Gunter, Marc J.
Murphy,
Neil
Riboli, Elio
Gonzalez, Carlos A.
