Περίληψη:
Carotenoids and vitamins A, C and E are possibly associated with a
reduced colorectal cancer (CRC) risk through antioxidative properties.
The association of prediagnostic plasma concentrations and dietary
consumption of carotenoids and vitamins A, C and E with the risk of
colon and rectal cancer was examined in this case-control study, nested
within the European Prospective Investigation into Cancer and Nutrition
study. Plasma concentrations of carotenoids (alpha- and beta-carotene,
canthaxanthin, beta-cryptoxanthin, lutein, lycopene, zeaxanthin) and
vitamins A (retinol), C and E (alpha-, beta- and gamma-and
delta-tocopherol) and dietary consumption of beta-carotene and vitamins
A, C and E were determined in 898 colon cancer cases, 501 rectal cancer
cases and 1,399 matched controls. Multivariable conditional logistic
regression models were performed to estimate incidence rate ratios (IRR)
and corresponding 95% confidence intervals (CIs). An association was
observed between higher prediagnostic plasma retinol concentration and a
lower risk of colon cancer (IRR for highest quartile = 0.63, 95% CI:
0.46, 0.87, p for trend = 0.01), most notably proximal colon cancer (IRR
for highest quartile = 0.46, 95% CI: 0.27, 0.77, p for trend = 0.01).
Additionally, inverse associations for dietary beta-carotene and dietary
vitamins C and E with (distal) colon cancer were observed. Although
other associations were suggested, there seems little evidence for a
role of these selected compounds in preventing CRC through their
antioxidative properties.
Συγγραφείς:
Leenders, Max
Leufkens, Anke M.
Siersema, Peter D.
van
Duijnhoven, Franzel J. B.
Vrieling, Alina
Hulshof, Paul J. M.
and van Gils, Carla H.
Overvad, Kim
Roswall, Nina
Kyro,
Cecilie
Boutron-Ruault, Marie-Christine
Fagerhazzi, Guy and
Cadeau, Claire
Kuehn, Tilman
Johnson, Theron
Boeing, Heiner
and Aleksandrova, Krasimira
Trichopoulou, Antonia
Klinaki, Eleni
and Androulidaki, Anna
Palli, Domenico
Grioni, Sara and
Sacerdote, Carlotta
Tumino, Rosario
Panico, Salvatore and
Bakker, Marije F.
Skeie, Guri
Weiderpass, Elisabete
Jakszyn,
Paula
Barricarte, Aurelio
Maria Huerta, Jose
Molina-Montes,
Esther
Argueelles, Marcial
Johansson, Ingegerd
Ljuslinder,
Ingrid
Key, Timothy J.
Bradbury, Kathryn E.
Khaw, Kay-Tee
and Wareham, Nicholas J.
Ferrari, Pietro
Duarte-Salles, Talita
and Jenab, Mazda
Gunter, Marc J.
Vergnaud, Anne-Claire
Wark,
Petra A.
Bueno-de-Mesquita, H. B(as)
