Τίτλος:
Maternal occupation during pregnancy, birth weight, and length of
gestation: combined analysis of 13 European birth cohorts
Περίληψη:
Objectives We assessed whether maternal employment during pregnancy
overall and in selected occupational sectors - is associated with birth
weight, small for gestational age (SGA), term low birth weight (LBW),
length of gestation, and preterm delivery in a population-based birth
cohort design.
Methods We used data from >200 000 mother-child pairs enrolled in 13
European birth cohorts and compared employed versus non-employed women.
Among employees, we defined groups of occupations representing the main
sectors of employment for women where potential reproductive hazards are
considered to be present. The comparison group comprised all other
employed women not included in the occupational sector being assessed.
We performed meta-analyses of cohort-specific estimates and explored
heterogeneity.
Results Employees had a lower risk of preterm delivery than
non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence
interval (95% CI) 0.81-0.91]. Working in most of the occupational
sectors studied was not associated with adverse birth outcomes. Being
employed as a nurse was associated with lower risk SGA infants (ORadj,
0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased
risk of preterm delivery (ORadj 1.50, 95% CI 1.12-2.02). There was
little evidence for heterogeneity between cohorts.
Conclusions This study suggests that, overall, employment during
pregnancy is associated with a reduction in the risk of preterm birth
and that work in certain occupations may affect pregnancy outcomes. This
exploratory study provides an important platform on which to base
further prospective studies focused on the potential consequences of
maternal occupational exposures during pregnancy on child development.
Συγγραφείς:
Casas, Marbe
Cordier, Sylvaine
Martinez, David
Barros,
Henrique
Bonde, Jens Peter
Burdorf, Alex
Costet, Nathalie
and dos Santos, Ana Cristina
Danileviciute, Asta
Eggesbo, Merete
and Fernandez, Mariana F.
Fevotte, Joelle
Garcia, Ana M. and
Grazuleviciene, Regina
Hallner, Eva
Hanke, Wojciech and
Kogevinas, Manolis
Kull, Inger
Larsen, Pernille Stemann and
Melaki, Vasiliki
Monfort, Christine
Nordby, Karl-Christian and
Andersen, Anne-Marie Nybo
Patelarou, Evridiki
Polanska, Kinga
and Richiardi, Lorenzo
Santa Marina, Loreto
Snijder, Claudia and
Tardon, Adonina
van Eijsden, Manon
Vrijkotte, Tanja G. M. and
Zugna, Daniela
Nieuwenhuijsen, Mark
Vrijheid, Martine
