Τίτλος:
The role of microRNAs in the pathogenesis of endometrial cancer: a
systematic review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Epigenetics seem to play a primary role in the current research on the
pathogenesis of different types of endometrial cancer. Data so far
indicate that microRNAs regulate different pathways that could lead to
carcinogenesis when not functioning properly. The aim of this review is
to summarize current knowledge on microRNAs that have been associated
with endometrial cancer development.
From July 2014 to August 2014, we conducted a comprehensive research
utilizing major online search engines (Pubmed, Crossref, Google
Scholar). The main keywords used in our search were endometrial
cancer/carcinoma; microRNA; epigenetics; novel biomarkers; pathogenesis.
Overall, we identified 155 studies, although only 77 were eligible for
this review. Different miRNAs were identified to contribute either
promoting the carcinogenesis in the endometrium or inhibiting different
steps of endometrial cancer development. Tumour growth, cell
proliferation, apoptosis and invasion metastasis have been identified as
the main processes where miRNAs seem to be implicated.
microRNAs are effective regulators of gene expression that has a
significant role in the pathogenesis of endometrial cancer. Research
concerning possible therapeutic implications has been promising,
although there is still a significant distance to be covered between
research observations and clinical results. Extensive preclinical and
translational research is still required to improve the efficacy and
minimize unwanted effects of miRNAs-based therapy.
Συγγραφείς:
Sianou, Argiri
Galyfos, George
Moragianni, Dimitra and
Andromidas, Panagiotis
Kaparos, Georgios
Baka, Stavroula and
Kouskouni, Evangelia
Περιοδικό:
Archives of Gynecology and Obstetrics
Εκδότης:
Springer Berlin Heidelberg
Λέξεις-κλειδιά:
Micrornas; Endometrial cancer; Carcinogenesis; Apoptosis; Metastasis;
Epithelial to mesenchymal transition
DOI:
10.1007/s00404-015-3660-y
