Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3167965 54 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Analysis of Heritability and Shared Heritability Based on Genome-Wide
Association Studies for 13 Cancer Types
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Studies of related individuals have consistently
demonstrated notable familial aggregation of cancer. We aim to estimate
the heritability and genetic correlation attributable to the additive
effects of common single-nucleotide polymorphisms (SNPs) for cancer at
13 anatomical sites.
Methods: Between 2007 and 2014, the US National Cancer Institute has
generated data from genome-wide association studies (GWAS) for 49 492
cancer case patients and 34 131 control patients. We apply novel mixed
model methodology (GCTA) to this GWAS data to estimate the heritability
of individual cancers, as well as the proportion of heritability
attributable to cigarette smoking in smoking-related cancers, and the
genetic correlation between pairs of cancers.
Results: GWAS heritability was statistically significant at nearly all
sites, with the estimates of array-based heritability, h(l)(2), on the
liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the
combined heritability of multiple smoking characteristics, we calculate
that at least 24% (95% confidence interval [CI] = 14% to 37%) and
7% (95% CI = 4% to 11%) of the heritability for lung and bladder
cancer, respectively, can be attributed to genetic determinants of
smoking. Most pairs of cancers studied did not show evidence of strong
genetic correlation. We found only four pairs of cancers with marginally
statistically significant correlations, specifically kidney and testes
(rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and
pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic
lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung
(rho = 0.35, SE = 0.14). Correlation analysis also indicates that the
genetic architecture of lung cancer differs between a smoking population
of European ancestry and a nonsmoking Asian population, allowing for the
possibility that the genetic etiology for the same disease can vary by
population and environmental exposures.
Conclusion: Our results provide important insights into the genetic
architecture of cancers and suggest new avenues for investigation.
Έτος δημοσίευσης:
2015
Συγγραφείς:
Sampson, Joshua N.
Wheeler, William A.
Yeager, Meredith and
Panagiotou, Orestis
Wang, Zhaoming
Berndt, Sonja I.
Lan,
Qing
Abnet, Christian C.
Amundadottir, Laufey T.
Figueroa,
Jonine D.
Landi, Maria Teresa
Mirabello, Lisa
Savage, Sharon
A.
Taylor, Philip R.
De Vivo, Immaculata
McGlynn, Katherine
A.
Purdue, Mark P.
Rajaraman, Preetha
Adami, Hans-Olov and
Ahlbom, Anders
Albanes, Demetrius
Amary, Maria Fernanda
An,
She-Juan
Andersson, Ulrika
Andriole, Jr., Gerald
Andrulis,
Irene L.
Angelucci, Emanuele
Ansell, Stephen M.
Arici,
Cecilia
Armstrong, Bruce K.
Arslan, Alan A.
Austin, Melissa
A.
Baris, Dalsu
Barkauskas, Donald A.
Bassig, Bryan A. and
Becker, Nikolaus
Benavente, Yolanda
Benhamou, Simone
Berg,
Christine
Van Den Berg, David
Bernstein, Leslie
Bertrand,
Kimberly A.
Birmann, Brenda M.
Black, Amanda
Boeing, Heiner
and Boffetta, Paolo
Boutron-Ruault, Marie-Christine
Bracci,
Paige M.
Brinton, Louise
Brooks-Wilson, Angela R. and
Bueno-de-Mesquita, H. Bas
Burdett, Laurie
Buring, Julie and
Butler, Mary Ann
Cai, Qiuyin
Cancel-Tassin, Geraldine and
Canzian, Federico
Carrato, Alfredo
Carreon, Tania
Carta,
Angela
Chan, John K. C.
Chang, Ellen T.
Chang, Gee-Chen and
Chang, I-Shou
Chang, Jiang
Chang-Claude, Jenny
Chen,
Chien-Jen
Chen, Chih-Yi
Chen, Chu
Chen, Chung-Hsing and
Chen, Constance
Chen, Hongyan
Chen, Kexin
Chen, Kuan-Yu and
Chen, Kun-Chieh
Chen, Ying
Chen, Ying-Hsiang
Chen, Yi-Song
and Chen, Yuh-Min
Chien, Li-Hsin
Chirlaque, Maria-Dolores and
Choi, Jin Eun
Choi, Yi Young
Chow, Wong-Ho
Chung, Charles C.
and Clavel, Jacqueline
Clavel-Chapelon, Franoise
Cocco,
Pierluigi
Colt, Joanne S.
Comperat, Eva
Conde, Lucia and
Connors, Joseph M.
Conti, David
Cortessis, Victoria K. and
Cotterchio, Michelle
Cozen, Wendy
Crouch, Simon
Crous-Bou,
Marta
Cussenot, Olivier
Davis, Faith G.
Ding, Ti
Diver,
W. Ryan
Dorronsoro, Miren
Dossus, Laure
Duell, Eric J. and
Ennas, Maria Grazia
Erickson, Ralph L.
Feychting, Maria and
Flanagan, Adrienne M.
Foretova, Lenka
Fraumeni, Jr., Joseph F.
and Freedman, Neal D.
Freeman, Laura E. Beane
Fuchs, Charles and
Gago-Dominguez, Manuela
Gallinger, Steven
Gao, Yu-Tang and
Gapstur, Susan M.
Garcia-Closas, Montserrat
Garcia-Closas, Reina
and Gascoyne, Randy D.
Gastier-Foster, Julie
Gaudet, Mia M. and
Gaziano, J. Michael
Giffen, Carol
Giles, Graham G. and
Giovannucci, Edward
Glimelius, Bengt
Goggins, Michael and
Gokgoz, Nalan
Goldstein, Alisa M.
Gorlick, Richard
Gross,
Myron
Grubb, III, Robert
Gu, Jian
Guan, Peng
Gunter,
Marc
Guo, Huan
Habermann, Thomas M.
Haiman, Christopher A.
and Halai, Dina
Hallmans, Goran
Hassan, Manal
Hattinger,
Claudia
He, Qincheng
He, Xingzhou
Helzlsouer, Kathy and
Henderson, Brian
Henriksson, Roger
Hjalgrim, Henrik and
Hoffman-Bolton, Judith
Hohensee, Chancellor
Holford, Theodore R.
and Holly, Elizabeth A.
Hong, Yun-Chul
Hoover, Robert N. and
Horn-Ross, Pamela L.
Hosain, G. M. Monawar
Hosgood, III, H. Dean
and Hsiao, Chin-Fu
Hu, Nan
Hu, Wei
Hu, Zhibin
Huang,
Ming-Shyan
Huerta, Jose-Maria
Hung, Jen-Yu
Hutchinson, Amy
and Inskip, Peter D.
Jackson, Rebecca D.
Jacobs, Eric J. and
Jenab, Mazda
Jeon, Hyo-Sung
Ji, Bu-Tian
Jin, Guangfu and
Jin, Li
Johansen, Christoffer
Johnson, Alison
Jung, Yoo Jin
and Kaaks, Rudolph
Kamineni, Aruna
Kane, Eleanor
Kang, Chang
Hyun
Karagas, Margaret R.
Kelly, Rachel S.
Khaw, Kay-Tee and
Kim, Christopher
Kim, Hee Nam
Kim, Jin Hee
Kim, Jun Suk and
Kim, Yeul Hong
Kim, Young Tae
Kim, Young-Chul
Kitahara, Cari
M.
Klein, Alison P.
Klein, Robert J.
Kogevinas, Manolis and
Kohno, Takashi
Kolonel, Laurence N.
Kooperberg, Charles and
Kricker, Anne
Krogh, Vittorio
Kunitoh, Hideo
Kurtz, Robert
C.
Kweon, Sun-Seog
LaCroix, Andrea
Lawrence, Charles and
Lecanda, Fernando
Lee, Victor Ho Fun
Li, Donghui
Li, Haixin
and Li, Jihua
Li, Yao-Jen
Li, Yuqing
Liao, Linda M. and
Liebow, Mark
Lightfoot, Tracy
Lim, Wei-Yen
Lin, Chien-Chung
and Lin, Dongxin
Lindstrom, Sara
Linet, Martha S.
Link,
Brian K.
Liu, Chenwei
Liu, Jianjun
Liu, Li
Ljungberg,
Boerje
Lloreta, Josep
Di Lollo, Simonetta
Lu, Daru
Lund,
Eiluv
Malats, Nuria
Mannisto, Satu
Le Marchand, Loic and
Marina, Neyssa
Masala, Giovanna
Mastrangelo, Giuseppe and
Matsuo, Keitaro
Maynadie, Marc
Mckay, James
McKean-Cowdin,
Roberta
Melbye, Mads
Melin, Beatrice S.
Michaud, Dominique
S.
Mitsudomi, Tetsuya
Monnereau, Alain
Montalvan, Rebecca
and Moore, Lee E.
Mortensen, Lotte Maxild
Nieters, Alexandra and
North, Kari E.
Novak, Anne J.
Oberg, Ann L.
Offit, Kenneth
and Oh, In-Jae
Olson, Sara H.
Palli, Domenico
Pao, William
and Park, In Kyu
Park, Jae Yong
Park, Kyong Hwa and
Patino-Garcia, Ana
Pavanello, Sofia
Peeters, Petra H. M. and
Perng, Reury-Perng
Peters, Ulrike
Petersen, Gloria M.
Picci,
Piero
Pike, Malcolm C.
Porru, Stefano
Prescott, Jennifer and
Prokunina-Olsson, Ludmila
Qian, Biyun
Qiao, You-Lin
Rais,
Marco
Riboli, Elio
Riby, Jacques
Risch, Harvey A. and
Rizzato, Cosmeri
Rodabough, Rebecca
Roman, Eve
Roupret,
Morgan
Ruder, Avima M.
de Sanjose, Silvia
Scelo, Ghislaine
and Schned, Alan
Schumacher, Fredrick
Schwartz, Kendra and
Schwenn, Molly
Scotlandi, Katia
Seow, Adeline
Serra, Consol
and Serra, Massimo
Sesso, Howard D.
Setiawan, Veronica Wendy and
Severi, Gianluca
Severson, Richard K.
Shanafelt, Tait D. and
Shen, Hongbing
Shen, Wei
Shin, Min-Ho
Shiraishi, Kouya and
Shu, Xiao-Ou
Siddiq, Afshan
Sierrasesumaga, Luis
Sihoe, Alan
Dart Loon
Skibola, Christine F.
Smith, Alex
Smith, Martyn T.
and Southey, Melissa C.
Spinelli, John J.
Staines, Anthony and
Stampfer, Meir
Stern, Marianna C.
Stevens, Victoria L. and
Stolzenberg-Solomon, Rachael S.
Su, Jian
Su, Wu-Chou
Sund,
Malin
Sung, Jae Sook
Sung, Sook Whan
Tan, Wen
Tang, Wei
and Tardon, Adonina
Thomas, David
Thompson, Carrie A. and
Tinker, Lesley F.
Tirabosco, Roberto
Tjonneland, Anne and
Travis, Ruth C.
Trichopoulos, Dimitrios
Tsai, Fang-Yu
Tsai,
Ying-Huang
Tucker, Margaret
Turner, Jenny
Vajdic, Claire M.
and Vermeulen, Roel C. H.
Villano, Danylo J.
Vineis, Paolo and
Virtamo, Jarmo
Visvanathan, Kala
Wactawski-Wende, Jean
Wang,
Chaoyu
Wang, Chih-Liang
Wang, Jiu-Cun
Wang, Junwen
Wei,
Fusheng
Weiderpass, Elisabete
Weiner, George J.
Weinstein,
Stephanie
Wentzensen, Nicolas
White, Emily
Witzig, Thomas E.
and Wolpin, Brian M.
Wong, Maria Pik
Wu, Chen
Wu, Guoping
and Wu, Junjie
Wu, Tangchun
Wu, Wei
Wu, Xifeng
Wu,
Yi-Long
Wunder, Jay S.
Xiang, Yong-Bing
Xu, Jun
Xu, Ping
and Yang, Pan-Chyr
Yang, Tsung-Ying
Ye, Yuanqing
Yin, Zhihua
and Yokota, Jun
Yoon, Ho-Il
Yu, Chong-Jen
Yu, Herbert and
Yu, Kai
Yuan, Jian-Min
Zelenetz, Andrew
Zeleniuch-Jacquotte,
Anne
Zhang, Xu-Chao
Zhang, Yawei
Zhao, Xueying
Zhao,
Zhenhong
Zheng, Hong
Zheng, Tongzhang
Zheng, Wei
Zhou,
Baosen
Zhu, Meng
Zucca, Mariagrazia
Boca, Simina M. and
Cerhan, James R.
Ferri, Giovanni M.
Hartge, Patricia
Hsiung,
Chao Agnes
Magnani, Corrado
Miligi, Lucia
Morton, Lindsay M.
and Smedby, Karin E.
Teras, Lauren R.
Vijai, Joseph
Wang,
Sophia S.
Brennan, Paul
Caporaso, Neil E.
Hunter, David J.
and Kraft, Peter
Rothman, Nathaniel
Silverman, Debra T. and
Slager, Susan L.
Chanock, Stephen J.
Chatterjee, Nilanjan
Περιοδικό:
JNCI Journal of the National Cancer Institute
Εκδότης:
OXFORD UNIV PRESS INC
Τόμος:
107
Αριθμός / τεύχος:
12
Επίσημο URL (Εκδότης):
DOI:
10.1093/jnci/djv279
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