Περίληψη:
Despite a strong association between body weight and mortality in the
general population, clinical evidence suggests better clinical outcome
of overweight or obese individuals with established coronary heart
disease. This finding has been termed the `obesity paradox', but its
existence remains a point of debate, because it is mostly observed when
body mass index (BMI) is used to define obesity. Inherent limitations of
BMI as an index of adiposity, as well as methodological biases and the
presence of confounding factors, may account for the observed findings
of clinical studies. In this review, our aim is to present the data that
support the presence of a BMI paradox in coronary heart disease and then
explore whether next to a BMI paradox a true obesity paradox exists as
well. We conclude by attempting to link the obesity paradox notion to
available translational research data supporting a `healthy', protective
adipose tissue phenotype. (C) 2016 World Obesity
Συγγραφείς:
Antonopoulos, A. S.
Oikonomou, E. K.
Antoniades, C. and
Tousoulis, D.
