A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3184305 64 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
A worldwide perspective of sepsis epidemiology and survival according to
age: Observational data from the ICON audit
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To investigate age-related differences in outcomes of
critically ill patients with sepsis around the world.
Methods: We performed a secondary analysis of data from the prospective
ICON audit, in which all adult ( >16 years ) patients admitted to
participating ICUs between May 8 and 18, 2012, were included, except
admissions for routine postoperative observation. For this sub-analysis,
the 10,012 patients with completed age data were included. They were
divided into five age groups - <= 50, 51-60, 61-70, 71-80, >80 years.
Sepsis was defined as infection plus at least one organ failure.
Results: A total of 2963 patients had sepsis, with similar proportions
across the age groups (<= 50 = 25.2%: 51-60 = 30.3%; 61-70 = 32.8%;
71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and
in patients >80 years was almost twice that of patients <= 50 years
(493% vs 25.2%, p < .05). The maximum rate of increase in mortality
was about 0.75% per year, occurring between the ages of 71 and 77
years. In multilevel analysis, age > 70 years was independently
associated with increased risk of dying.
Conclusions: The odds for death in ICU patients with sepsis increased
with age with the maximal rate of increase occurring between the ages of
71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved.
Έτος δημοσίευσης:
2019
Συγγραφείς:
Kotfis, Katarzyna
Wittebole, Xavier
Jaschinski, Ulrich and
Sole-Violan, Jordi
Kashyap, Rahul
Leone, Marc
Nanchal, Rahul
and Fontes, Luis E.
Sakr, Yasser
Vincent, Jean-Louis
Tomas,
E.
Bibonge, E. Amisi
Charra, B.
Faroudy, M.
Doedens, L.
and Farina, Z.
Adler, D.
Balkema, C.
Kok, A.
Alaya, S.
and Gharsallah, H.
Muzha, D.
Temelkov, A.
Georgiev, G. and
Simeonov, G.
Tsaryanski, G.
Georgiev, S.
Seliman, A. and
Vrankovic, S.
Vucicevic, Z.
Gornik, I
Barsic, B. and
Husedzinovic, I
Pavlik, P.
Manak, J.
Kieslichova, E. and
Turek, R.
Fischer, M.
Valkova, R.
Dadak, L.
Dostal, P.
and Malaska, J.
Hajek, R.
Zidkova, A.
Lavicka, P. and
Starkopf, J.
Kheladze, Z.
Chkhaidze, M.
Kaloiani, V and
Medve, L.
Sarkany, A.
Kremer, I
Marjanek, Z.
Tamasi, P.
and Krupnova, I
Vanags, I
Liguts, V
Pilvinis, V and
Vosylius, S.
Kekstas, G.
Balciunas, M.
Kolbusz, A. and
Kubler, A.
Mielczarek, B.
Mikaszewska-Sokolewicz, M.
Kotfis,
K.
Tamowicz, B.
Sulkowski, W.
Smuszkiewicz, P.
Pihowicz,
A.
Trejnowska, E.
Hagau, N.
Filipescu, D.
Droc, G. and
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Tolkach,
A.
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Palibrk, I
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Bumbasirevic, V
Uljarevic, B.
and Surbatovic, M.
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Aguilar,
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Montoiro Allue, R.
Argueso, M.
Parejo, M.
Palomo
Navarro, M.
Jose, A.
Nin, N.
Alvarez Lerma, F.
Martinez,
O.
Tenza Lozano, E.
Arenal Lopez, S.
Perez Granda, M. and
Moreno, S.
Llubia, C.
De la Fuente Martos, C. and
Gonzalez-Arenas, P.
Llamas Fernandez, N.
Gil Rueda, B. and
Estruch Pons, I
Cruza, N.
Maroto, F.
Estella, A.
Ferrer,
A.
Iglesias Fraile, L.
Quindos, B.
Quintano, A.
Tebar,
M.
Cardinal, I
Reyes, A.
Rodriguez, A.
Abella, A. and
Garcia Del Valle, S.
Yus, S.
Maseda, E.
Berezo, U. and
Tejero Pedregosa, A.
Laplaza, C.
Ferrer, R.
Rico-Feijoo, U.
and Rodriguez, M.
Monedero, P.
Eriksson, K.
Lind, D. and
Chabanel, D.
Zender, H.
Heer, K.
Frankenberger, B. and
Jakob, S.
Mathew, S.
Downes, R.
Groba, C. Barrera and
Johnston, A.
Meacher, R.
Keays, R.
Haji-Michael, P. and
Tyler, C.
Ferguson, A.
Jones, S.
Tyl, D.
Ball, A. and
Vogel, U.
Booth, M.
Downie, P.
Watters, M.
Brett, S. and
Garfield, M.
Everett, L.
Heenen, S.
Dhir, S.
Beardow, Z.
and Mostert, M.
Brosnan, S.
Pinto, N.
Harris, S. and
Summors, A.
Andrew, N.
Rose, A.
Appelboam, R.
Davies, O.
and Vickers, E.
Agarwal, B.
Szakmany, T.
Wimbush, S. and
Welters, I
Pearse, R.
Hollands, R.
Kirk-Bayley, U. and
Fletcher, N.
Bray, B.
Brealey, D.
ICON Investigators
Περιοδικό:
Journal of Critical Care
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Τόμος:
51
Σελίδες:
122-132
Λέξεις-κλειδιά:
Mortality; Outcome; ICU
Επίσημο URL (Εκδότης):
DOI:
10.1016/j.jcrc.2019.02.015
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