Τίτλος:
HLA Polymorphisms and Food Allergy Predisposition
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Food allergy (FA) is a growing health problem that affects similar to
8% of the children worldwide. Although the prevalence of FA is
increasing, the underlying genetic mechanisms responsible for the onset
of this immune disorder are not yet clarified. Genetic factors seem to
play a leading role in the development of FA, though interaction with
environmental factors cannot be excluded. The broader network of genetic
loci mediating the risk of this complex disorder remains to be
identified. The human leucocyte antigen (HLA) has been associated with
various immune disorders, including FA. This review aims to unravel the
potential associations between HLA gene functions and the manifestation
and outcome of FA disorders. Exploring new aspects of FA development
with the perspective to improve our understanding of the multifaceted
etiology and the complex biological mechanisms involved in FA is
essential.
Συγγραφείς:
Kostara, Maria
Chondrou, Vasiliki
Sgourou, Argyro
Douros,
Konstantinos
Tsabouri, Sophia
Περιοδικό:
Journal of Pediatric Genetics
Εκδότης:
Georg Thieme Verlag KG
Λέξεις-κλειδιά:
food allergy; HLA system; genetic predisposition
DOI:
10.1055/s-0040-1708521
