Τίτλος:
Renal handling of zinc in chronic kidney disease patients and the role
of circulating zinc levels in renal function decline
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Zinc deficiency is commonly encountered in chronic kidney
disease (CKD). The aims of this study were to assess whether zinc
deficiency was related to increased renal excretion of zinc and to the
progression of CKD.
Methods. Plasma and 24-h urinary zinc levels, urinary electrolytes and
uromodulin were measured in 108 CKD patients and 81 individuals without
CKD. Serum creatinine values were collected for 3 years to calculate the
yearly change in estimated glomerular filtration rate (eGFR).
Multivariable regression analysis was performed to assess the
association between baseline zinc levels and yearly change in eGFR.
Results. CKD patients had lower circulating zinc levels and higher 24-h
urinary zinc excretion than non-CKD participants (612.4 +/- 425.9 versus
479.2 +/- 293.0 mu g/day; P = 0.02). Fractional excretion (FE) of zinc
was higher and it significantly increased at more advanced CKD stages.
Zinc FE was correlated negatively with 24-h urinary uromodulin excretion
(r= -0.29; P < 0.01). Lower baseline plasma zinc levels were associated
with a faster yearly decline of renal function in age, gender, diabetes
and hypertension adjusted models, but this relationship was no longer
significant when baseline eGFR or proteinuria were included.
Conclusions. Zinc levels are lower in CKD, and not compensated by
reduced renal zinc excretion. The inverse association between urinary
zinc excretion and uromodulin possibly points to an impaired tubular
activity, which could partly account for zinc imbalance in CKD. These
data suggest that zinc status is associated with renal function decline,
but further studies elucidating the underlying mechanisms and the
potential role of zinc supplements in CKD are needed.
Συγγραφείς:
Damianaki, Katerina
Lourenco, Joao Miguel
Braconnier, Philippe
and Ghobril, Jean-Pierre
Devuyst, Olivier
Burnier, Michel and
Lenglet, Sebastien
Augsburger, Marc
Thomas, Aurelien
Pruijm,
Menno
Περιοδικό:
Nephrology Dialysis Transplantation
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
CKD; GFR; uromodulin; zinc excretion; zinc renal handling
