Unit:
Τομέας ΚλινικοεργαστηριακόςLibrary of the School of Health Sciences
Dissertation committee:
Τσακρής Αθανάσιος, Βρυώνη Γεωργία, Σπανάκης Νικόλαος
Original Title:
Ανίχνευση και τυποποίηση ιών γρίπης σε λοιμώξεις του αναπνευστικού
Summary:
Information on the drug susceptibility of influenza epidemic strains is
important for antiviral resistance
monitoring. In Greece, the 2009–2010 pandemic waves were very mild and
seroprevalence rates
remained low after this influenza season, resulting in exclusive detection of
the pandemic strain during
the 2010–2011 influenza season. In the present study during the post-pandemic
2010–2011 season, 50
consecutive influenza A(H1N1) 2009 virus-positive samples from patients
hospitalised in Greek hospitals
were analysed for resistance to the neuraminidase inhibitor oseltamivir. All
patients were hospitalised
with severe influenza complications and had previously received oseltamivir.
Influenza A(H1N1) 2009
virus detection and testing for oseltamivir resistance were performed with
real-time PCR amplification
assays. The H275Y substitution associated with resistance to oseltamivir was
identified in two immunocompetent
patients who received oseltamivir treatment for 3 days and 5 days,
respectively. In both cases,
patients were discharged in good condition despite development of resistance to
antiviral treatment.
Keywords:
Influenza, Oseltamivir, Detection, Mutation, Resistance
Number of references:
257
