Summary:
The purpose of the current study was to determine the frequency of HPV DNA
detection, as well as to identify low- risk and high- risk HPV genotypes in
primary head and neck squamous cell carcinomas (HNSCCs). 137 histological and
cytological samples were obtained from patients with HNSCCs (58 oral cavity, 54
larynx, 12 oropharynx, 5 hypopharynx, 5 nasopharynx and 3 nasal cavity).The
overall prevalence of HPV DNA positive HNSCCs was 17.5%, while HPV 16 was the
commonest genotype detected in 6.6% followed by HPV 18, HPV 6, HPV 33 and HPV
51. According to the results of themultivariate logistic regression analysis,
HPV DNA positivity was independently associated with poorly differentiated
tumors (OR, 4.00; 95% CI, 1.43 - 11.4, p= 0.006), possibly reflecting a
distinct clinical entity attributable to HPV infection.
Keywords:
HPV, Cancer, Head, Neck, Virus
