Τομέας Παθολογίας
Library of the School of Health Sciences

2014-02-06

2014

Χατζηγιάννη Κυριάκου Αμαλία

Ομότιμος καθηγητής Παύλος Τούτουζας

Ανίχνευση υπερτασικών ασθενών με επιρρέπεια για ανάπτυξη κολπικής μαρμαρυγής: συσχέτιση με παραμέτρους από το ηλεκτροκαρδιογράφημα, το υπερηχοκαρδιογράφημα, την 24ωρη ΗΚΓ καταγραφή ρυθμού, την 24ωρη καταγραφή αρτηριακής πιέσεως και βιοχημικές παραμέτρους

Greek

Identification of hypertensive subjects who are predisposed to develop atrial fibrillation and correlate the latter with parameters from the surface electrocardiogram, the 24-h ambulatory blood pressure, the 24-h holter monitoring, the echocardiographic study and laboratory measurements

The purpose of the present study was to identify hypertensive subjects who are
predisposed to develop atrial fibrillation (AF) and correlate the latter with
parameters from the surface electrocardiogram (ECG), the 24-h ambulatory blood
pressure (BP), the 24-h holter monitoring, the echocardiogrphic study and
laboratory measurements.To investigate the hypothesis, from the general
population of hypertensive subjects in sinus rhythm presenting in the
Outpatient Clinic, we recruited 50 subjects with a documented episode of
paroxysmal AF (PAF group, age 63±9 y) and 50 subjects with no history of AF
(non AF group, age 49±8 y). All study participants underwent 24-h ambulatory BP
and Holter monitoring, 12-lead ECG for Pdisp assessment, a complete
transthoracic echocardiographic study, routine biochemical profile assessment
and finally, determination of 1) hs-CRP and endothelin-1, as markers of
subclinical inflammation as well as 2.The present study, apart from confirming
that hypertensive subjects with a history of paroxysmal AF are characterized by
elevated CRP levels and greater values of Pdisp, demonstrated for the first
time the association between Pdisp and CRP values. This findings support the
notion that low grade inflammation is implicated in the electrophysiological
remodeling of the atria in the setting of paroxysmal AF in hypertension.
Moreover, natriuretic peptide levels (BNP and ANP) could be a significant and
reliable index for the detection of patients prone to the development of PAF
among essential hypertensive patients in sinus rhythm.

Atrial fibrillation, Hypertension, CRP, Inflammation, P wave dispersion

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https://pergamos.lib.uoa.gr/uoa/dl/object/1305704