Τομέας Χειρουργικής
Library of the School of Health Sciences

2013-05-20

2013

Τζιούπης Χριστόφορος

Γεώργιος Παπαχρήστου, Αναπληρωτής Καθηγητής Ορθοπαιδικής, Νικόλαος Ευσταθόπουλος, Αναπληρωτής Καθηγητής Ορθοπαιδικής, Ανδρέας Λάζαρης, Αναπληρωτής Καθηγητής Παθολογικής Ανατομικής.

Ανοσοϊστοχημική, απεικονιστική και εμβιομηχανική μελέτη βιολογικών φαινομένων σε πειραματικό μοντέλο διαταραχών πωρώσεως.

Greek

Background:Despite the progress accomplished towards the treatment of fractures
in recent years, impaired healing is still one of the most severe
complications. In this context, the field of Bone Tissue Engineering emerges as
a promising alternative aiming at bone regeneration.
Objective:The aim of this study was to investigate the efficacy of the
implementation of biomimetic scaffolds alone or in combination with PRP and
BMSCs in terms of their ability to heal critical-size defects. Materials and
Methods:NWZ rabbits were subjected to ulnar osteotomy (15mm) and the void was
filled with biomimetic scaffolds alone or in combination with PRP and BMSCs.
After 8 weeks, all animals were sacrificed. The samples were subjected to
histological, imaging (xray, CT, micro-CT) and biomechanical assessment.
Results:All animals survived without any complications. The scaffolds proved
highly biocompatible and exerted a high degree of bone regenerative capacity,
especially when they were seeded with PRP and BMSCs. Histological assessment
revealed the existence of mature lamellar bone in all groups. Based on the
3D-histomorphometry, the biomimetic scaffolds yielded superior results when
seeded with PRP and BMSCs. Conclusions:The implementation of biomimetic
scaffolds is a safe alternative approach in the treatment of nonunions
especially when seeded with PRP and BMSCs.

PRP, BMSCs, Bone Tissue Engineering

No

0

Yes

229

xxxiii, 138

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https://pergamos.lib.uoa.gr/uoa/dl/object/1305748