Unit:
Τομέας Κοινωνικής Ιατρικής - Ψυχιατρικής και ΝευρολογίαςLibrary of the School of Health Sciences
Author:
Kατσιαρδάνη Καλλιόπη-Πηνελόπη
Dissertation committee:
Επ. Καθηγήτρια Εργαστήριο Υγιεινής και Επιδημιολογίας και Ιατρικής Στατιστικής Νάσκα Ανδρονίκη, Αν. Καθηγητής Β Ψυχιατρικής Κλινικής ΕΚΠΑ Δουζένης Αθανάσιος, Αν. Καθηγήτρια Α Ψυχιατρικής ΚλινικήςΤσάλτα Ελευθερία
Original Title:
Διατροφή, κατάθλιψη και γνωσιακή έκπτωση: πληθυσμιακή προσέγγιση σε υπερήλικες, γεωγραφικά οριοθετημένης περιοχής της Μαγνησίας.
Translated title:
Dietary-Depression and Cognitive Impairement among eldery a population-based approach in a closed geographical area of Magnesia
Summary:
Περίληψη στα Αγγλικά
There is accumulating evidence on the association between vitamin complex B
levels in blood and the risk of depression and/or cognitive impairment among
elderly people. In the context of the "VELESTINO" study, data were collected
through interviewer-administered questionnaires and blood samples were taken
among elderly, aged 65 years and over. Depression was assessed through the
Geriatric Depression Scale-GDS 15 (GDS>6) and cognitive impairment, through the
Mini Mental State Examination-MMSE (MMSE23). In the analysis, the prevalence
of depression was estimated and multivariate logistic regression models were
applied to assess the association of depression with serum levels of folic acid
and vitamin B12. The study findings were further combined to those of other
cross-sectional studies in a meta-analysis. The prevalence of depression was
high in the population under study (50.7%), with the conditions being more
prevalent among women than men. (62,3 % vs 36, 1% ). Among women, the
prevalence of depressive symptoms was positively associated with age and
inversely associated with serum levels of folic acid (1st vs. 3rd tertile, OR:
2.08, 95% CI: 1.07-4.05) controlling for vitamin B12. Among men, depression was
inversely associated with the index of family/social support (OR: 0.46, 95% CI:
0.31-0.68, one level increase of the index). Among men, depression was
positively associated with cognitive impairment (OR: 2.21, 95% CI: 1.26-3.87).
In the meta-analysis, low levels of vitamin B12 in serum were associated with
depression among elderly females (OR: 1.33, 95% CI: 1.02-1.74, fixed effects
model), while folate levels were not found to be associated with depression in
either men or women.
Keywords:
Diet, Depressiom, Biomarkers, Cognitive impairment, Velestino study
Number of references:
300
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