Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences

2013-02-22

2013

Βλάχος Ηλίας

Αναπλ. Καθ. Π. Νικολοπούλου - Σταμάτη

Διερεύνηση του πιθανού διαμεσολαβητικού ρόλου των πρωτεινών θερμικού σοκ ανάμεσα στο ψυχοφυσιολογικό στρες και τις οργανικές παθήσεις. Η περίπτωση των ιδιοπαθών φλεγμονωδών νόσων του εντέρου.

Greek

The investigation of the possible mediating role of heat shock proteins between psychophysiological stress and organic disease. The case of inflammatory bowel disease

Objective : to investigate the hypothesis that depression and anxiety levels
could be associated with the induction of the antiapoptotic Heat Shock Protein
70 (HSP70) in the colon of patients with inflammatory bowel disease (IBND),
namely ulcerative colitis and Crohn's Disease.
Methods: 54 consecutive hospitalized IBD patients in relapse gave their
informed consent , filled out psychometric questionnaires (Zung Depression
Rating Scale. Spielberger State Trait Anxiety Inventory, Hospital Anxiety and
Depression Scale (HADS). Simultaneously , intestinal biopsies were taken to be
diagnosed in a blinded manner by two pathologists. The type and severity of
inflammation were assessed on each section with hematoxylin/eosin staining. The
localazition and intensity of expression of HSP70 expression were studied
immunohistochemically.Results: There was statistixally significant correlation
between depression and anxiety levels and inducible HSP70 in the
polyumorphonuclear cells (PMN) of patients with active CD.

Inflammatory Bowel Disease, Anxiety, Depression, Heat Shock Proteins, Psychoneuroimmunology

Yes

9-11

Yes

178

154

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1306075