Summary:
Osteoporosis a silent, progressive, systemic skeletal disease characterized by
impaired bone architecture with decreased bone mass density affecting women in
menopausal and after menopausal stage and men in the third age, mainly in the
ratio 6:1. Periodontitis a chronic inflammatory, multifactorian disease has
been associated with general osteoporosis .
Statins, inhibitor of HMG-CoA-reductase, seems to interfere in bone formation
exerting anabolic and antiresorptive effect.
The study investigates the bone density in mandible and femur in an
ovariectomized (OVX) rat model of osteoporosis in order to test the effect of
simvastatin on bone size parameters.
50 Wistar female rats aged 4-6 weeks, weighting 200-300g were randomized in
five groups. Animals in Group 1,2 and 3 (n=10) were overiectomized and group 4
and 5 serve as contols. Group 2,3 and 5 were treated with simvastatin 0,5
mg/kg/daily p.o. for 3 months. Sizes parameters of the isolated femur,
mandible and uterus were measured, BMD(bone mass density) via dual energy X-Ray
absorptiometry (DEXA) and laboratory serum findings were estimated.
Ovariectomy leads to experimental menopause with decreased uterus weight and
reduction of all parameters in femur and mandible (weight, specific weight,
bone weight /body weight ) that have been restored under the influence of
statins. DEXA results showed significant decrease of BMD in ovariectomy group
/ controls while statins treatment decrease the severity of BMD lose. The serum
IL-13 as osteogenesis index seems to be positive influenced by statins
treatment.
Keywords:
Statins, Osteoporosis, Rats, Ovariectomy, Bone density
