Unit:
Τομέας Υγείας - Μητέρας - ΠαιδιούLibrary of the School of Health Sciences
Dissertation committee:
Μαρία Παπαγρηγορίου Θεοδωρίδου, Αλεξάνδρα Μαρία Μαγιάκου, Ευαγγελία Παπαδαυίδ
Original Title:
Ηωσινοφιλική κατιονική πρωτεΐνη (ECP) στην ενεργό ατοπική δερματίτιδα στα παιδιά. Συσχέτιση με ευαισθητοποίηση σε κοινά αλλεργιογόνα
Translated title:
Eosinophilic cationic protein (ECP) in children with acute atopic dermatitis. Correlation with sensitization to common allergens
Summary:
Eosinophilic cationic protein (ECP) in children with acute atopic dermatitis.
Correlation with sensitization to common allergens
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease of
childhood. Although eosinophilic cationic protein (ECP) levels are elevated in
AD, their potential to predict allergen-specific IgE sensitization has rarely
been studied. Furthermore, only a few studies exist about the natural course of
early AD.
Materials: 89 infants with AD, aged 3 to 24 months, were recruited and various
parameters were determined. 56 patients were followed up for 7 years.
Results: ECP serum levels and blood eosinophil count were significantly higher
in patients with allergen sensitization. Correlation of ECP with total IgE
levels and severity were statistically significant. AD persistence at the age
of 7 years (28,6% of patients), was significantly related only with severity.
The initial severity score of AD and food allergy was found to be associated
with a higher frequency of asthma appearance. Patients developing asthma had
significantly higher serum ECP levels at the initial evaluation.
Conclusion: Serum ECP values were significantly associated with the antigen
specific IgE sensitization in infants with AD and demonstrated a predictive
ability for later development of asthma. The severity of the disease was the
major outcome predictor for AD persistence in later childhood and appearance of
asthma.
Keywords:
atopic dermatitis, children, Eosinophilic cationic protein, sensitization to allergens, atopic dermatitis in children
Number of references:
163
