Unit:
Τομέας ΚλινικοεργαστηριακόςLibrary of the School of Health Sciences
Author:
Ραφαηλίδης Πέτρος
Dissertation committee:
Λ. Νακοπούλου, Καθηγήτρια, Π. Κορκολοπούλου, Καθηγήτρια, Α. Λάζαρης, Καθηγητής
Original Title:
Aνοσοiστοχημική μελέτη της έκφρασης της κινάσης ΕRK2 και των πρωτεiνών των μεταγραφικών παραγόντων ETS-1 και φωσφορυλιωμένης STAT-1 σε διηθητικά καρκινώματα του μαστού
Translated title:
Immunohistochemical study of the expression of ERK2 kinase and of the proteins of the transcriptional factors ETS-1 and phosphorylated STAT-1 in invasive breast carcinomas
Summary:
The immunohistochenmical expression of ERK2 kinase(a mitogen activated protein
kinase) and of the transcriptional factor proteins ETS-1 and phosphorylated
STAT-1 was studied in paraffin sections of surgical specimens of 151 patients
with a diagnosis of invasive breast carcinoma. Τhe present study for the first
time indicates that the ERK2 kinase, ETS-1 protein and pSTAT-1 protein
signaling pathway has a distinctive role in women with breast cancer.
Specifically, compartmentalization of ERK2, as revealed by its immunodetection
in the cytoplasm and nuclei of breast cancer cells, reflects a different effect
on patient survival, with nuclear ERK2 being prognostic of a shortened overall
survival and cytoplasmic localization being an independent favorable
prognosticator of both disease-free and overall survival. In addition, ETS-1
seems to be related to a different tumor phenotype according to its topographic
distribution, with nuclear localization being associated with decreased
cumulative survival in postmenopausal women. Furthermore, our results suggest
that pSTAT-1 is related to tumor progression in premenopausal patients through
the advanced stage and decreased cumulative survival. Hence, further
investigation of the ERK2 kinase, ETS-1 protein and pSTAT-1 protein signaling
pathway might be crucial for exploring new therapy targets.
Keywords:
ERK2 kinasi, ETS-1 protein, p-STAT-1 protein, Immunohistochemistry, Invasive breast cancer
Number of references:
484
