Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Μέμου Αθηνά Μαρία
Supervisors info:
Μαστοράκος Γεώργιος, Αναπληρωτής Καθηγητής(Επιβλέπων) Γελαδάς Νικόλαος , Καθηγητής, Βαλσαμάκης Γεώργιος, Ενδοκρινολόγος-Διαβητολόγος, Επιστημονικός Συνεργάτης
Original Title:
Ανασκόπηση του ρόλου της βισφατίνης και της απελίνης στη μεταβολή της ενδοθήλιο-εξαρτώμενης αγγειοδιαστολής (FMD) και στην έκκριση ινσουλίνης σε νορμοβαρείς γυναίκες με σύνδρομο πολυκυστικών ωοθηκών μετά από δοκιμασία άσκησης
Summary:
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common
endocrinopathy of women. According to International Institute of Health
(NIH), women who suffer from polycystic ovarian syndrome are more than
10% and in accordance with the general criteria of Rotterdam reach 20%.
Apelin, visfatin and Flow-mediated Dilation are studied in this review as well
as the effect of exercise in women with PCOS.
Results: FMD is reduced in women with PCOS and it is highlighted that these
women have resistance to insulin.. Apelin’s levels are reduced in contrast to
the levels of visfatin which are elevated. Exercise improves the above factors.
Also, it has been shown that aerobic exercise resulted in lower levels of
visfatin and higher levels of apelin compared to the group which had
sedentary life. There are no enough data for review on the role of exercise in
the effect of visfatin and apelin in the PCOS group compared to control group.
Conclusions: FMD is a risk factor for cardiovascular disease, suggesting
endothelial dysfunction in women with PCOS. Also, apelin may indicate a
protective role even though two studies showed adverse effects, highlighting
the relation of PCOS and obesity. Visfatin may be associated with visceral fat
and endothelial function and its reduced after exercise probably as a result of
weight loss and changes in body composition. . Exercise has beneficial role in
endothelial function and in many metabolic parameters.
Keywords:
Visfatin, Apelin, Flow-mediated Dilation , Exercise, Insulin
Number of references:
163
