Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences

2015-11-18

2015

Τρυφέρη Ελένη

Νικόλαος Παπαντωνίου, Εμμανουήλ Σαλαμαλέκης, Δημήτριος Κασσάνος

Αυτοάνοσα νοσήματα και κύηση

Greek

Autoimmune diseases and pregnancy

Autoimmune diseases affect a large proportion of women of reproductive age. In
many autoimmune diseases Th1 immune responses dominate (rheumatoid arthritis,
multiple sclerosis, psoriasis) and reduction in disease activity during
pregnancy with a postpartum relapse are expected in most cases. For diseases in
which the Th2 immune response predominates, such as systemic lupus
erythematosus, the incidence of relapse increases during pregnancy.
Pregnancy is an induced state of immune tolerance of maternal immune system
towards the semi-allogenic fetus. After the 8th to 12th week of pregnancy Th2
helper lymphocytes and antiinflammatory cytokines IL-3, IL-4, IL-5 and IL-10
predominate.
Each pregnancy with a co-existing autoimmune disease should be considered from
the beginning as a high risk pregnancy. Prenatal counseling is necessary, so
that the patients can be aware of the interaction between their disease, their
medication and pregnancy. Gestational ultrasound, Doppler (uterine vessels,
middle cerebral and umbilical artery), cardiotocographic control and assessment
of fetal biophysical profile help significantly to prevent both maternal and
fetal complications. Effective control of disease activity in combination with
the minimization of complications are the goals of therapy during pregnancy.

Autoimmune diseases, Pregnancy complications, Remit, Prenatal counselling, Management

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310305