Summary:
Bone morphogenetic proteins (BMPs) are growth factors who belong to TGF-b
hyperfamily and are produced to the bone matrix.
BMP-7 is the mainly acting BMP to the kidneys where her actions have been
widely studied although many BMPs (BMP-2,BMP-3, BMP-4, BMP-6) have been found
in minimal concentrations.
In nephrogenesis, BMP-7 acts by induction promoting acting signals for the
differentiation of metanephric mesenchyme
In acute renal failure, BMP-7 minimizes renal insult by inhibiting
inflammation reactions and the following renal fibrosis through reducing the
expression of pro-inflammatory cytokines and chemokines, respectively. Also
BMP-7 restores renal blood flow through acting to the expression of ET-2, HO-1
and ADORA-1.
In chronic renal failure, BMPs (and especially BMP-7) have remarkable positive
actions to her pathophysiologic actions as chronic renal fibrosis, diabetic
nephropathy, secondary hyperparathyroidism, adynamic bone disease and vascular
calcinosis.
Finally, it has been shown that BMPs have treatment actions to the acute and
chronic renal failure and to experimental models of obstructive nephropathy,
acute glomerulonephritis, lupus nephritis and hypertensive nephrosclerosis.
Keywords:
Bone morphogenetic proteins, Kidney, Acute renal failure, Chronic renal failure, Nephrogenesis
