Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2012-07-26

2012

Κουράνος Βασίλειος

Αναπλ. Καθηγητής Συρίγος Κωνσταντίνος (επιβλέπων), Αναπλ. Καθηγήτρια Ρούσσου Παρασκευή , Διδάκτωρ Μούντζιος Ιωάννης

Εξωνοσοκομειακές λοιμώξεις σε ασθενείς με καρκίνο του πνεύμονα

Greek

Ιntroduction: Infections are important causes of morbidity and mortality in
lung cancer patients.
Methods: This prospective study included all patients with lung cancer who
referred with signs or symptoms of possible infection between September 2009
and October 2011. Primary outcomes included the presence of febrile neutropenia
(FN), the need for hospitalization, and the overall mortality.
Results: Seventy one patients were enrolled in this study with febrile episodes
and/or microbiologically or otherwise documented infection. 46 patients (64.8%)
presented with non-small cell lung carcinoma, while 22/71 patients (31%) and
3/71 patients (4.2%) had small cell lung cancer and mesothelioma respectively.
Fifteen patients (21.1%) presented with FN and totally 43/71 (60.6%) patients
required hospitalization for parenteral therapy upon admission. The predominant
site of the infections was the lung in 59/71 patients (83.1%). In the
hospitalized setting 3 episodes of bacteremia with Staphylococcus aureus were
reported and microbiologically documented infections accounted for 26.7%. The
overall mortality rate was 9.8%, while only 1 patient died in the outpatient
setting despite the antibiotic therapy.
Conclusion: This study showed that early detection and control of infection in
lung cancer patients receiving therapy may improve their survival while
recogniting the predisposing factors for infections and possible therapy
toxicities.

lung cancer, febrile neutropenia, hospitalization, mortality, infection

No

0

Yes

182

127

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/1311134