Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2014-03-14

2014

Ράλλη Μαρία

Κωνσταντίνος Συρίγος, Βασίλειος Κουλούλιας, Μιχάλης Τουμπής

Η επίδραση της ακτινοθεραπείας θώρακα στην πνευμονική λειτουργία ασθενών με καρκίνο πνεύμονα

Greek

Introduction: Lung radiation therapy constitutes a frequent and necessary
therapeutic option on patients with non small cell lung cancer or small cell
lung cancer, used either as monotherapy or in combination with systematic
chemotherapy.
Methods: This prospective study includes all patients with lung cancer, who
referred to the respiratory medicine department and were to undergo lung
radiotherapy between September 2009 and October 2012. Spirometry before and
after the use of bronchodilators, lung capacity, and diffusing capacity of
carbon monoxide tests were used to measure lung function. The lung function
evaluation of patients, undergoing lung radiation, took place just before the
initiation of radiotherapy and a month after radiotherapy was completed.
Results: Eighty-one lung cancer patients undergoing radiotherapy were enrolled
in this study. Thirty patients failed to complete the radiotherapy protocol.
Nineteen patients (37.2%) were diagnosed with non-small cell lung carcinoma
[10/19 (52.6%) with adenocarcinoma stage IIIB/IV, and 9/19 (47.4%) with
squamous cell carcinoma stage IIB/IV]. Among the 32 patients (62.8%) with small
lung cancer cell, 12/32 (37.5%) presented with limited disease and 20/32
(62.55%) presented with extended disease. The first evaluation visit revealed
29/51(56.8%) patients with obstructive syndrome and 21/51 (41.2%) with
reduction of the diffusing capacity of carbon monoxide. The second evaluation
visit, following the completion of the radiotherapy, demonstrated 34/51 (66.6%)
patients with FVC improvement, 32/51 (62.7%) with FEV1 improvement and 35/51
(68.6%) DLCO improvement. The statistical analysis of pulmonary parameters
revealed no statistically significant differences.
Conclusion: The radiation effect on pulmonary function depends on multiple
parameters, such as the patient’s comorbidities, the lung cancer stage, the
response to chemotherapy. The evaluation and prediction of these parameters
constitutes a complex and challenging issue.

Radiotherapy, Lung cancer, Spirometry, Postradiation pneumonitis, Lung toxicity

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https://pergamos.lib.uoa.gr/uoa/dl/object/1311576