Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences

2015-11-19

2015

Αθανασοπούλου Χρηστίνα

Ομότιμος Kαθηγητής Νικόλαος Παπαντωνίου

Μεσογειακή αναιμία και κύηση

Greek

Thalassemic syndromes are the most common monogenic disease. They are
characterized by the absence or mutation of the α and β globulin chains genes,
which result in reduced HbA synthesis. Depending on the immunoglobulin chain
defected they are divided in α and β, while depending on the number of globulin
genes affected, are divided in homozygous and heterozygous. Homozygous is
characterized by severe anemia, extramedullary erythropoiesis and peripheral
hemolysis. It is treated via transfusions and iron chelation.
Materials-methods: The purpose is the bibliographical review of thalassemic
syndromes and their correlation to a successful pregnancy, healthy mother and
infant. The material used was based on scientific databases, scientific
documents and scientific magazines’ articles (66 references , 53 english and
13 greek).
Results: Homozygous β-thalassemia’s various complications occur due to
ineffective erythropoiesis and iron overload (endocrine, bones, respiratory
function). The more severe are cardiac and hepatic dysfunction, and viral
infections. The ability of pregnancy achievement and its positive outcome
depends on the maternal general condition and subjects to interdisciplinary
approach. Pregnancy itself does not affect the process of the disease, it may
though indirectly affect the function of already affected organs. No increased
risk of fetal loss or obstetric complications has been noticed.
Conclusions: Thalassemia patients can reproduce under the conditions of good
former health and close medical monitoring before and during the pregnancy.

Thalassemia, Pregnancy, Fertility

No

0

Yes

66

143

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https://pergamos.lib.uoa.gr/uoa/dl/object/1312605