Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Μανουσαρίδης Ιορδάνης
Supervisors info:
Αν.Καθ. Ν. Παπαιωαννου
Original Title:
Μεταβολικές διαταραχές στο τραύμα
Summary:
Trauma is defined as cellular disruption caused by an exchange with
environmental energy that is beyond the body's resilience. In order to increase
the chances of surviving injury, animals have evolved a complex set of
neuroendocrine mechanisms that act locoregionally and systemically to try to
restore the body to its pre-injury condition. Metabolic response to injury
includes hyperglycemia, insulin resistance, increased hepatic insulin
production and muscle protein catabolism. While these responses act
beneficially in mild trauma, they prove to be self-destructive in extended
injuries. Effective management is achieved with the treatment of the underlying
cause (shock, injury, inflammation), thus interrupting the metabolic response
at the beginning of its activation.
Keywords:
Trauma, Metabolic response, Inflammantory response, Immunense response, Stress
File:
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