Speciality Clinical Neuropsychology
Library of the School of Health Sciences

2012-07-11

2012

Νίντος Ανδρέας

Ιωάννης Ζαλώνης (επιβλέπων), Κωνσταντίνος Πόταγας, Νικόλαος Σμυρνής

Μετωποκροταφική δυσλειτουργία στην πλάγια μυατροφική σκλήρυνση: ανάλυση διακρίνουσας εξίσωσης

English

Recent research shows that cognitive deficits found in ALS often indicate
frontotemporal dysfunction (FTd), with reported prevalence reaching up to 52%.
In the present study thirty four ALS patients, 44-89 years old, were tested
with a brief neuropsychological battery, including executive, behavioral, and
language measures. Patients were initially classified as FTd and nonFTd
according to FAB. Between group comparisons revealed significant differences
for all measures (p < 0.01). Discriminant analysis produced one function with
all tests serving as significant predictors. This function recognized 15
patients as FTd, whereas classification with the FAB placed 17 patients in this
group. An optimal cut-off function score equal or bigger than 0.0846 showed
that ALS-FTd could be distinguished from ALS-nonFTd with 88.2% specificity and
88.2% sensitivity. We stress the importance of discriminant function analysis
in clinical neuropsychological assessment, and argue that the proposed
neuropsychological battery is of clinical utility, for psychometric but also
clinical and ethical reasons. The psychometric validity of an ALS-FTD diagnosis
using neuropsychological tests is also discussed.

Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Frontotemporal Dysfunction, Discriminant function analysis, brief neuropsychological battery

No

0

Yes

33

19

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/1312675