Unit:
Κατεύθυνση Κλινική ΦαρμακευτικήLibrary of the School of Science
Supervisors info:
Μαρκαντώνη-Κυρούδη Σοφία Καθηγήτρια (επιβλέπουσα), Δάλλας Παρασκευάς Επίκ. Καθηγητής ΕΚΠΑ, Ράλλης Μιχάλης Επίκ. Καθηγητής ΕΚΠΑ
Original Title:
Επίδραση της κρέμας μαδεκασόλης (1% εκχύλισμα Centella asiatica) στην αναστολή του ερυθήματος που προκαλείται από ακτινοθεραπεία στο δέρμα του ασθενούς με καρκίνο του μαστού
Translated title:
Effect of madecassol cream (1% Centella asiatica) on the inhibition of radiation-induced skin erythema of patients with breast cancer
Summary:
BACKGROUND: The development of acute radiation erythema is a common phenomenon
among patients undergoing radiotherapy treatment. Currently, management is
based on several medicinal herbs to the prevention and management of radiation
toxicity.
OBJECTIVE: The aim of this study was to assess the effectiveness of Madecassol
cream (1% centella asiatica extract) for the prevention of acute radiation
erythema in breast cancer patients receiving radiotherapy (RT).
METHODS: This work was carried out in the 'Andreas Syggros' Hospital of
Cutaneous & Venereal Diseases and in the 'I.METAXA' Anticancer Hospital. 30
breast cancer patients were prospectively enrolled in the study and were
divided into 2 groups of 15 each. Group I (control) was treated with Bepanthol
cream (5% provitamin B5), group II was treated with Madecassol (1% centella
asiatica extract). The grade of radiation dermatitis was examined during and
after RT completion.
RESULTS: All patients completed the planned RT and were compliant with
instructions for applying the study cream (Madecassol cream 1%) and Bepanthol
cream. In 11 Group I (control Group) patients (73%) Grade 3 radiation
dermatitis developed and in 4 patients (27%) Grade 2. In comparison radiation
dermatitis of maximum grade 3, 2, and 1 developed in 1 (7%), 12 (80%), and 2
(13%), respectively. Group II showed lower incidence of grade 3 radiation
dermatitis than the control group, the results were found to be statistically
significant P <0.05.
CONCLUSION: The prophylactic use of Madecassol cream 1% (extract of centella
asiatica) was shown to reduce the incidence of high grade radiation dermatitis
suggesting a promising role of Madecassol cream as a supportive treatment to
improve compliance and quality of life in patients undergoing radiation
therapy.
Keywords:
Breast cancer, Radiation dermatitis, Madecassol cream, Centella asiatica extract
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