Unit:
Κατεύθυνση Βιομηχανική ΦαρμακευτικήLibrary of the School of Science
Author:
Κατσίνη Αδαμαντία
Supervisors info:
Παρασκευάς Δάλλας Επίκ. Καθηγητής ΕΚΠΑ (επιβλέπων), Δημήτριος Ρέκκας Αναπλ. Καθηγητής ΕΚΠΑ, Εμμανουήλ Εφεντάκης Αναπλ. Καθηγητής ΕΚΠΑ
Original Title:
Μελέτη και βελτιστοποίηση φορέα διαδερμικής χορήγησης ρισπεριδόνης με εφαρμογή πειραματικού σχεδιασμού μιγμάτων
Translated title:
In vitro study and optimization of the permeation of risperidone using IV Optimal Mixture Design
Summary:
In the present study, the in vitro permeation of risperidone was investigated
through human cadaver epidermis, using Franz diffusion cells. The aim was to
evaluate a suitable vehicle for transdermal delivery of risperidone, as a
first step regarding the development of a transdermal therapeutic system with
desired flux, using IV Optimal Mixture Design, provided by Design Εxpert
software.
The objective was to formulate hydroxypropyl methylcellulose gels (2% HPMC
E4M), in a mixed solvent system consisting of EtOH/Glycerol Formal/H2O. The
proportions of the three cosolvents which were selected to be examined were:
10-40 % ΕtOH, 0-30 % Glycerol Formal and 40-90 % Η2Ο. The responses of the
design of experiments were solubility and permeability of risperidone through
human epidermis.
Τhe results showed that the coexistence of the three (co) solvents and the
proper adjustment of the composition of the cosolvent system was necessary to
maximize and significantly improve the permeability of risperidone. Thus, a
synergistic effect has been found for EtOH combined with Glycerol Formal on
solubility and permeability of risperidone.
The optimal ratios of the cosolvents were: 16-32% EtOH ,10-30% Glycerol Formal,
47-59% H2O. These vehicles (containing 0,7-1% w/w risperidone) showed
permeabilities after 72 h, ranged from 465-510 μg/cm2. which satisfy the
requirements of the minimum daily oral dose with the development of TDDS of 10
cm2 and the maximum one, with the development of TDDS of 40 cm2, respectively.
It was concluded that IV Optimal Mixture Design proved to be suitable to
maximize the permeability of risperidone and minimize drug dose, showing
promising prospects for transdermal delivery of risperidone.
Keywords:
Risperidone, Transdermal, Design, Mixture, Permeation
Number of references:
150
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