Κατεύθυνση Οργανική Χημεία
Library of the School of Science

2014-06-18

2014

Κυρίτση Αντιγόνη-Αγγελική

Γεώργιος Κόκοτος Καθηγητής (Επιβλέπων), Σταματία Βασιλείου Λέκτορας, Βικτωρία Μαγκριώτη Λέκτορας

Σύνθεση Η- φωσφινικών οξέων ως πιθανών ενζυμικών αναστολέων

Greek

Synthesis of H- phosphinic acids as possible enzyme inhibitors

Chapter 1 describes the structure of autotaxin, its physiological and
pathological activities and also the most important types of inhibitors.
Chapter 2 describes thiamides, a functional group similar to amides, which
occurs from substitution of the carbonyl oxygen with sulfur. A review of the
ways they can be synthesized, their proteolytic and biological behavior and the
hydrogen bonds they can form.
Chapter 3 is a review of the chemistry of phosphinic acids, covering from
older, named reactions such as Arbuzov, Pudovik, phospha-Michael to modern
methods like the use of organometallic catalysis.
Chapter 4 presents the methology behind the synthesis of the inhibitors of
the present assay. Inhibitors are categorized into three groups depending on
the reaction used for the formation of the P-C bond.
In chapter 5 the experimental procedures and the spectroscopic data of the
molecules of the present work are described.
Finally, some indicative NMR spectras of typical compounds of this work are
quoted.

Inhibitors, Thiamides, Phosphinic acids

Yes

7-13, 110

Yes

129

128

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1319986