Unit:
ΠΜΣ με ειδίκευση ΣΥΝΘΕΤΙΚΗ ΦΑΡΜΑΚΕΥΤΙΚΗ ΧΗΜΕΙΑLibrary of the School of Science
Author:
Σεραφίδου Αγγελική - Θεοδώρα
Supervisors info:
Τσοτίνης Ανδρέας Καθηγητής (Επιβλέπων), Μαράκος Παναγιώτης Καθηγητής, Πουλή Νικολαϊς Καθηγήτρια
Original Title:
Σύνθεση νέων παραγώγων της φαινόλης και της ναφθόλης με μελατονινεργική δράση
Translated title:
Synthesis of new derivatives of phenol and naphthol with melatonergic action
Summary:
The present MSc dissertation was carried out in the Department of
Pharmaceutical Chemistry
of the Faculty of Pharmacy, University of Athens, in the context of the
Postgraduate Programme
“Synthetic Pharmaceutical Chemistry”. In this work, the design, synthesis and
melatoninergic action
of new derivatives of phenol and naphthol are described.
Melatonin is a pineal hormone directly involved in the regulation of the
circadian rhythms in
mammals and in man. Thus far, numerous structure-activity relation studies have
been published on
molecules with melatoninergic activity, in an attempt to understand the
molecular mechanism of
action of melatonin, and this work constitutes an extension of this ongoing
research.
In the introductory part of this MSc dissertation, an account of the main
characteristics of the
hormone, along with its biosynthesis and metabolism, is given. This is followed
by a brief
description of the receptors of melatonin and of the theoretical models
available describing its
possible binding mode(s) to these receptors. In the last section of this
chapter, the targets and scope
of the present work are presented.
The retrosynthetic and synthetic methods followed for the preparation of the
new molecules
are presented in detail in the next chapter, which is concluded by the
description of the
pharmacological protocols employed and the test results obtained for the new
compounds.
Keywords:
Melatoninergic activity, Circardian rythms, Xenopus laevis, Pineal hormone, Melatonin
