Unit:
Τομέας ΙΙΙ [Ανόργανη Χημεία – Ανόργανη Χημική Τεχνολογία – Περιβαλλοντική Χημεία]Library of the School of Science
Author:
Πατινιώτη Ζαμπελού
Supervisors info:
Χ. Μητσοπούλου Καθηγήτρια (Επιβλέπουσα), Κ. Μεθενίτης Αναπληρωτής Καθηγητής, Κ. Δημόπουλος Καθηγητής
Original Title:
Aλληλεπίδραση των συμπλόκων του Re(CO)3Clpq και [Cu(dppz)(pq)]BF4 με dna και βιολογική δράση έναντι PAF και θρομβίνης
Summary:
In this thesis we carried out the synthesis and characterization of the
Re(CO)3Clpq and [Cu(dppz)(pq)]BF4 complexes using spectrofotometric methods
like NMR, F.T.-IR, UV -Vis chromatography and CV. These complexes were studied
in their interaction with calf thymus DNA (C.T.-DNA). The interaction was
studied with UV-Vis spectrometry, Circular Dichroism, Thermal Duration
experiments, Viscometry and Cyclic Voltammetry. All experiments were carried
out at pH=7 (tris HCl buffer). In addition, we studied the activity of these
complexes as potential inhibitors towards Platelet
Activating Factor (PAF) and thrombin (Thr).
Keywords:
diimine complexes, Rhenium(I), Copper(I), DNA, PAF
Number of index pages:
1-12
Number of references:
179
File:
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